New Book~Beyond Hormone Therapy(options 4 PCa)~Mark Moyad, MD, MPH-2011

Would you read a book on PCa drug therapies???
Nope...I flip a coin on such things (lol) - 12.5%
Yep...I would read almost anything on PCa - 75.0%
I need my docs approval to read anything (lol) - 12.5%

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Date Joined Dec 2008
Total Posts : 3149
   Posted 6/24/2011 8:04 PM (GMT -6)   
Well envolved in reading Mark's newest book just out apparently and plenty on drug therapies, explanations of HT therapies spelled out better for some people to comprehend, and drugs in trials with possible results, things to help prevent or lessen any side effects on therapies, good and useful nutrition and more.  Really good information and on some of the latest drugs and therapies, including Provenge, Abiraterone, Jevtana. Explainations, and side effects disclosed and doseages usually mentioned or other tidbits. Covers most drugs we might have heard of in reasonable fashion.
Your future drugs in Clinical Trials mentioned in this book with some details, info:
Aflibercept (VEGF Trap)-injection or IV
Atrasentan (Xinlay)-pill
Dasatinib (Sprycel)- pill  (approved in off label for other reasons already)
Ipilimumab (MDX-010)- IV
Lenalidomide (Revlimid)- pill    (already approved for other treatments)
MDV3100 (aka-super casodex)- pill     (also same inventor has ARN509, similar too)
OGX-011 (custirsen sodium)- IV
Prostvac (poxviral vaccine)- injection
Radium-223  (Alpharadin)- IV
XL184 (Cabozantinib)- pill
Zibotentan (ZD4054)- pill
Alot of those are in phase III clinical trials, so possibly getting approval in reasonable time frames. Mentioned in his book sometimes you can get these drugs without approval by pleading for 'Compassionate useage' concept...some have been obtained as such, some are listed as available under those parameters (aka) in the book. This is historically a good time period going on in PCa investigations and researching things, much more can be done including combinations of these drugs and sequencing ideas.  Back in 2002 you had much less in options for hrpca treatments, so some improvement is happening.
Can be bought at  (around $15.00 discounted from $20 range) :-)   

Post Edited (zufus) : 6/24/2011 8:34:57 PM (GMT-6)

Veteran Member

Date Joined Dec 2010
Total Posts : 3555
   Posted 6/24/2011 10:29 PM (GMT -6)   
Thanks Zufus, you are great at finding these and alerting us to them.

Moyad's was the first book my uro refferred me to. He is a great nutritiontionalist. I will order this.
PSA 59 on 8-26-2010 age 60. Biopsy 9-8-2010 12/12 positive, 20-80% involved, PNI in 3 cores, G 3+3,3+4,and 4+3=G7, T2b.
Eligard shot and daily Jalyn started on 10-7-2010.
IMRT to prostate and lymph nodes 25 fractions started on 11-8-2010
HDR Brachytherapy December 6 and 13-2010.
PSA <.1 and T 23 on 2-3-2011.
PSA <.1 on 4-7-2011
Second Eligard shot on 4-7-2011

Jerry L.
Veteran Member

Date Joined Feb 2010
Total Posts : 3042
   Posted 6/26/2011 4:18 AM (GMT -6)   
Thanks Zufus. I am encouraged by the new therapies under research and slowly being offered as options.

Will order it today.
Nov. 2009 Dx at Age 44
Dec. 2009 DaVinci Robotic Surgery
Jan. 2010 T3b, Gleason 9
Feb. 2010 Adjuvant Radiation
March 2011 PSA Rise/scan indicates spot
April, 2011 Casodex / Lupron
May 2011 Radiation to pelvic bone

PSA History:
Nov. 2009 4.30
Feb. 2010 <.05
May 2010 <.05
Aug. 2010 <.05
Nov. 2010 <.05
March, 2011 .09
April, 2011 .06

Veteran Member

Date Joined Nov 2009
Total Posts : 7187
   Posted 6/26/2011 7:48 PM (GMT -6)   
Has anyone perused this book? I can't even find a description. It sounds very worthwhile.

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 6/27/2011 5:07 AM (GMT -6)   
Google about the book- Mark has a Facebook page on this too. Available at barnesandnobles, amazon and likely some others.

Example of tidbits from this book: Albumin a protein measure by a blood test can be a good indicator that the body is doing well when receiving treatments, abnormally low level could be an indicator otherwise.

Those whom got reasonable response from casodex, usually can find more response in similar family of drugs: Nilandron or Exeulin

Clinical Trials info on the process of Trials I thru IV- inof on pages 26-29

Ketoconazole- info page 46-48

Zometa (also Exgeva) bone health assistance drugs pages 53-62

DEXA-scan (Dual-Energy X-ray Absorptiometry) xray scan info and-
(QCT) Quantitative Computerized Tomography (QCT) page 121

Estrogenic drugs:
DES (pill) no patents (ran out in early 1980's), compounded useages 1,2,3 mg's
Ethinyl estradiol (pill)
Estradurin (injectable, aka polyestradiol phosphate)
Fosfestrol (pill)
Estradiol patches (Vivelle-Dot) another is Mylan

Plenty more in the book, also about dealing with various side effects and how to counter some of those. Recommend and has the Zufus Good House Sleeping-Approval (LOL)!!! tongue

Regular Member

Date Joined Nov 2009
Total Posts : 485
   Posted 6/27/2011 5:26 AM (GMT -6)   
Zufus,  Thanks for posting the info on the book.  I ordered it from Amazon yesterday.  Have you read the section on nutrition?  Just curious if it has a lot of useful information.

Dx 2/2008, at age 71, PSA 9.1, G8, T1c
daVinci surgery 5/2008, G8(5+3), pT2c,N0,MX,R0
BCR 2 1/2 yrs after surgery
IMRT, 68.4 Gy, 12/2010 - 2/2011
PSA 0.07 three months after IMRT

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 6/27/2011 6:05 AM (GMT -6)   
I went quickly over the section on Diet, Supplements and Alternative Medicine info because that is a lesser interest to me overall, I have read some of his earlier books on such and not much changes in his findings or philosophy and those types of things. His other multiple pages on Preventing and Lessening Side Effects has information that some would find useful for sure. He has good amount of written pages on those two subject lines I mentioned. The book is generally very good, and probably one of the better up to date books for laypeople to read. Covers a vast area of topics in shortened methods. Has appendix's in the back of the book 1 thru 4: #4 is advocacy and support orginizations with their weblinks, some of these would be new to many people. #3- Appendix: Imaging testings used, #2-appendix drugs in clinical trials 1 & 2 levels, #1 appendix: Off Label Drugs types available.

Someone else could write a book on the hormone and drug uses, that could be much more exhaustive and detailed and maybe someone like Dr. Myers will come out with such, who knows. I think people are looking for better overall information, photos, examples or cases like Dr. Strum used in his book would be real plus for readers, along with information and collaborated data and maybe weblinks, etc.
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