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Herindoors
New Member


Date Joined Jun 2011
Total Posts : 12
   Posted 6/28/2011 3:11 PM (GMT -6)   
Hello, I thought I would give you a little update on my last post :-)

We went to see the consultant today and my husband was diagnosed with PCa, gleason 7 (3+4) and the cancer is in the left side of the prostate which was why he had a negative DRE.

He is now having a bone scan in the next two weeks and a MRI at the end of July as they want the prostate to recover from the biopsy. The consultant is worried that there may possibly be mets as his PSA is 24.5 which is considered high for a gleason 7??...did I hear that wrong?

He will also be having a PSA test before the MRI so we can see what it is doing.

He has been offered surgery if the cancer is confined to the prostate or HT or chemo if it has spread.

Any thoughts would be appreciated
:-)

I am from England by the way.

60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 2222
   Posted 6/28/2011 7:41 PM (GMT -6)   
Hopefully it has not spread but that is a high PSA. Would hope that surgery or radiation and HT might be an option if it has spread. But keep us posted.
Michael
Dx with PCA 12/08 2 out of 12 cores positive 4.5 psa
59 yo when diagnosed, 61 yo 2010
Robotic surgery 5/09
Gleason upgraded to 3+5, volume less than 10%
2 pads per day, 1 depends but getting better,
started ED tx 7/17, slow go
Post op dx of neuropathy
T2C left lateral and left posterior margins involved
3 months psa.01, 6 month psa.4
Started IMRT Jan. 2010 72gys
7month post SRT PSA.27

JNF
Veteran Member


Date Joined Dec 2010
Total Posts : 3746
   Posted 6/28/2011 8:16 PM (GMT -6)   
I was gleason 7 and psa of 59. The doctors did not find or suspect mets, but started my treatment very aggressively with IMRT, HDR Brachytherapy, and ADT3. I also alterred my diet and supplements and picked up my exercise routine. So far so good as I have had two undetectable PSA readings and hope for another one next week. I just had my testosterone checked and it is <3, so the ADT is working.

The normal prostate gives off .66 psa per cc of volume. Cancer gives off more with gleason 7 giving off about 2 psa per cc of tumour. Based on a normal size prostate the psa 24 would indicate about 10 cc of tumour with could be about 30% of a normal sized prostate. Do you have the information as to the number of positive cores and the amount in each core? If the prostate is enlarged then more psa would come from the gland and less from the cancer. The doctor should be able to estimate this.

You will need to hit the cancer very hard as it is high risk. My docs say that it is usually worse than the biopsy shows.
PSA 59 on 8-26-2010 age 60. Biopsy 9-8-2010 12/12 positive, 20-80% involved, PNI in 3 cores, G 3+3,3+4,and 4+3=G7, T2b.
Eligard shot and daily Jalyn started on 10-7-2010.
IMRT to prostate and lymph nodes 25 fractions started on 11-8-2010
HDR Brachytherapy December 6 and 13-2010.
PSA <.1 and T 23 on 2-3-2011.
PSA <.1 on 4-7-2011
Second Eligard shot on 4-7-2011

Herindoors
New Member


Date Joined Jun 2011
Total Posts : 12
   Posted 6/28/2011 11:31 PM (GMT -6)   
JNF, they did a 12 core biopsy and all six on the left were positive, sorry, I don't know the %.
His prostate is said to be small and not enlarged at all.
Being a diabetic, he is on a good diet and does plenty of exercise with the job he does.

I think I need to prepare myself for mets?

az4peaks
Regular Member


Date Joined Feb 2011
Total Posts : 112
   Posted 6/29/2011 1:08 AM (GMT -6)   
Hi JNF and Herindoors, - A correction to JNF's Post.

JNF said, "The normal prostate gives off .66 psa per cc of volume.", but in fact, the multiplier should be .066.

Just so people are not confused or erroneously figuring 10 times the actual figure as the "normal" amount of PSA that should be present from benign tissue. A 24 cc Prostate consisting of only unaltered benign tissue would, theoretically, produce 1.58 ng/ml of PSA.

Readings above that amount would, theoretically, be due to other than "normal" PSA production. Prostatitis (Inflammation) and BPH (Benign Prostate Hyperplasia or Hypertrophy), both benign (non-Cancerous) conditions and/or PCa(Prostate Cancer) being the 3 most common causes. - John@newPCa.org (aka) az4peaks

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 6/29/2011 4:57 AM (GMT -6)   
Have you talked to an oncologist, if you do ask them how accurate are scans in general...likely you would hear more truthfulness on that, than what a uro-surgeon will just happen to tell you. Are you interested in total frankness on this subject of scans?

Herindoors
New Member


Date Joined Jun 2011
Total Posts : 12
   Posted 6/29/2011 5:33 AM (GMT -6)   
Zufus, I very much prefer frankness than fluffy rubbish to make one feel better !!
I like to know exactly what is what and who is who in the zoo.

I have big suspicions that with a small prostate with the left side cancerous together with a PSA that high, it is very likely to have spread?
would you agree?

Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 6/29/2011 7:00 AM (GMT -6)   
I sure hope that the cancer is contained within the prostate so it can be treated. Consulting with an Oncologist is a good idea. If it is contained you will have several treatment options from different sources. Good luck and please keep us posted.
Age: 67 at Dx on 12/30/08 PSA 3.8
2 cores out of 12 were positive Gleason (4+4)
Davinci surgery 2/9/09 Gleason 4+4 EPE,
Margins clear, nerve bundles removed
Prostate weighed 57 grams 10-20% involved
all PSA tests since (2, 5, 8, 11, 15, 18, 21, 2 years <.008? ) undetectable
27 months: .005
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