Nobody knows how it comes back. If they did they would try to prevent it if possible or explain it to you. All I know is that everyone with G6 OC like you that I have seen have radiation went back to undetecable. I also have read a study stating the same. I would guess that your recurrence is local. Who knows what spills out of you when they cut out your prostate.
It is also possible that your post op. pathology was wrong. I read a study that Johns Hopkins did which looked at 37 patients who were G6 organ confined that had recurrence. 26 of them where misclassified when they went back and re-examined their post-op pathologies. In the end only 11 were actually G6 organ confined. Some even had positive margins that were missed originally.
I believe you also mentioned that your original biosys was 3+4. Even though your post op was G6 OC, I believe that still puts you at somewhat of a higher risk.
Ask to have your post op slides sent to Johns Hopkins and have them re-examined.
Post Edited (ChrisR) : 10/9/2011 6:41:39 PM (GMT-6)