Here is some more on variants, and two that mention Gleason 6 patients and easily confused clinicians for finding these types. Exactly why patients should employ expert pathologists (few experts exist) and use expert oncologists who test for low psa but possible disease progression and markers that are useable.
You can google search PCa variants and find more info these days:www.propath.com/newsletters.../500-variants-of-prostate-carcinoma www.jama.ama-assn.org/content/306/13/1431.1.full
Partial info from propath link:
VARIANTS OF PROSTATE CARCINOMA by Bahram Robert Oliai, M.D.
Although the overwhelming majority of prostate cancers are acinar adenocarcinomas, behaving in accordance to their various Gleason scores, peculiar variants account for 5-10% of prostatic carcinomas (4,9). Additionally, there are some variants of acinar adenocarcinoma (psuedohyperplastic and foamy gland carcinoma) which tend to confuse both clinicians and pathologists for various reasons. Given the previously mentioned statistics, we are bound to run into these unusual cases at some time in our career. ===================================
(do read the rest of his info on some nasty variants like: Small cell, Mucinious, Singet ring, and such.) I am most curious about
the state of the art of average pathologists and what they actually can decipher.
Post Edited (zufus) : 11/11/2011 6:11:33 AM (GMT-7)