Thanks Ralph for this discussion. These are core issues that very much interest me. It will take a while but I'll see if I can find some research that sheds some light. I've been reading about
some of the genetic markers recently discovered, and they seem to shed some light as to which markers are found with which kind of tumor. I'm sure there are no solid answers just yet, but we're getting there.
I did find this recent entry in Prostate Cancer Infolink and referenced study to be quite intriguing: prostatecancerinfolink.net/2011/11/29/molecular-signatures-and-prediction-of-poor-prostate-cancer-outcomes-over-time/
Here's a tidbit:
Recent reports on mouse studies have proposed a progressive collaboration between early MYC amplification, loss of PTEN, and finally loss of p53, leading to invasive prostate cancer.
The study seemed to find less p53 loss in younger peoples' PCa stem cells. This suggests a different mechanism for this group, which wasn't discussed. Fascinating in a macabre way.
Age 60 Gleason 9
1/10 PSA 14.7
5/10 Bx: Gleason 3+4
8/4/2010 RRP: Gleason 4+5; Positive Margins, PNI
Incontinence: N/A; ED: 70%
Until 4/11, PSA <.01; 4/11: .01; 6/11: .03
ADT3 started 7/20; WPRT 39 sessions ended 10/14:
Pelvic lymph nodes: 45 Gy; Fossa 66 Gy; Prostate bed: 71.5 Gy.
Post Edited (Riviere) : 12/13/2011 10:56:01 AM (GMT-7)