Bro. Todd hope you get some results soon on your psa situation. I have to mention this as it may prove useful even in your current scenario, I have to find the link to the Journal article but an article from the year 2000 was presented to our seminar group and the findings within it seem bizarre but the testing done on PCa lymphnode cells (LNCap) within 'nude' mice (blind studies) showed excellent immediate results ( and 3 of patients here in Michigan already have done this with results),using a unique concept of a combo of two of the drugs that we know already are very useful in effecting PCa (androgens and anti-androgens). Whatever the mechanism when combined these two in the journal article showed very significant difference in PCa psa results atleast in short term results.
Not only is the conjecture, so called from a Journal article, 3 of us here in Michigan whom are long term fighters and have psa rising while on lupon and other drugs tried have within the last 2 months, decided to do this protocol and we all got lowered psa levels (significant lowering, too). How long will vary patient to patient and in my case might have only worked well for a couple months. The other guys got on going proven results, fyi.
Concept is this: androgen useage drug (Casodex-generic) + anti-androgen (estrogenic drugs: any of these DES, or estradiol patches or emcyt or using another acting like anti-androgen 'effectively speaking' called tamoxifene), when you combine the two different types for some reason (mechanism of binding to the SCR pathway of cancers) it will in fact lower your psa and have a positive effect. How long is the next big question. If you have any DES at home still and get generic casodex, you could in fact try it and in your case and do get a psa test within days or one week to see if that is the case and in treating high risk scenarios and longer term users on HT therapies you have to be aware of the possible increase in psa that can happen while on casodex (occassionally it can in fact feed PCa, so you drop it if that psa were to rise while on it) and in many patients whom experienced this phenomena increased psa's, the withdrawal from it AAWR can cause a lowering of psa immediately (gee another anomolie or bizarre thing within PCa). Even if you don't look at this information, hopefully someone else will not only look but try this combo and post the results found thereafte Looking outside the box might be worth a look....they don't have all the answers anyway as to a flight plan on manipulations on PCa....it varies from doc to doc...some of the best are the guys that are specialists in PCa and we have heard their names many times, herein.
Surprizingly and maybe not surprizingly this type of information is not well known.....of course there is no real money to be gleaned in this protocol and it may only be effective for awhile. But is another possibility and as we can see (hopefully) manipulation of drugs while fighting PCa can have great longer term results. I have a PCD (PCa guys total digest) whom is like a chess player on this and gets envolved big time in his own choices, trust me his long term fight and on going results are noteworthy, he gave me a copy of it. He has had increasing scenarios many times, but by manipulations has again and again kept his psa very low and likely avoiding mets, he was originally screened in 1996 with a psa that was higher than safe or normal. This info may not help much in your scenario, but can be helpful in other scenarios. He failed surgery and failed SRT, had Gleason 8's and his current psa is lowered now to around .33 and currently using Mylan estradiol patches (3-4) and casodex 50 mg. generic. Also, this protocol generally has very tolerable side effects and can be inexpensive too. If you are paranoid about DES (some have more risks for blood clots than others), then use estradiol patches or gels (considered very safe). Anyway would like to see if someone herein tries it and posts there results soon afterwards.
Anyway, best to whatever paths you decide to do. Just found this link after writting this, a trial in process right now using relaxifene (similar concept to tamoxifen) so the two drugs used (casodex and anti-androgen essentially).
Bicalutamide and Raloxifene in Treating
Patients With Metastatic or Hormone-Refractory Prostate Cancer [Recruiting]<!-- relevance: 0.9563-->
RATIONALE: Androgens can cause the
growth of prostate cancer cells. Antihormone therapy, such as bicalutamide, may
lessen the amount of androgens made by the body. Selective estrogen receptor
modulators, such as raloxifene, may work together with bicalutamide to stop the
growth of prostate cancer.
PURPOSE: This clinical trial studies giving bicalutamide and raloxifene
together in treating patients with metastatic or hormone-refractory prostate
Also read journal info: www.ncbi.nlm.nih.gov/pubmed/21622172 (interesting too)
Post Edited (zufus) : 2/15/2012 6:38:03 AM (GMT-7)