There are no simplistic rules in PCa, full of anomolies, inconsistencies and even exceptions. Hopefully a great onco-doc would know via blood panel testings and urine testings for bone break down, as to how aggressive it all is. Pathology by experts aka molecular pathology can help define some precise causes like over expressed AR (androgen receptor) and other genetic tests that can be done, let alone define does this patient have a variant type of PCa or even variant types happening (it can happen, just like having more than one Gleason scoring found, it may be rare but has happened). We in effect have imperfect pathology analysis as usually done right now, lousy scannings for the most part, and less than perfection in docs assessments (generally) and kind of rushed into many treatments and some patients assisted into not getting multiple opinions which might be in their best interests.
I would guess if you had a ploidy DNA analysis on the PCa, it is not diploid type anymore, those are more like normal cells and have dual even pairs of DNA chains. The weirded ones are aneuploid, and another I heard about
call teteraploid (spelling?) Three classes used to define DNA, as it gets away from Diploid status, the DNA chain ends up with randomness, broken chains, non-paired strands, then into say chaotic mess. (this can be tested original in pathology and some have done so, why it is not standard practice seems dumb to me), the more that can be known up front the better. Your pathology slides can be reviewed, stained for various specialized testings, and even molecular analysis can be done by a very few select pathologists whom know how to do such. Hope this quicky gives you an idea on PCa issues.
Zimac- what kinds of drugs is he using to fight his PCa, and do you have more info as to when drug failed and psa changes???? Checkout www.yananow.net (experiences to find 1000+ patients journies and histories and some have emails available, likely find similar patients)
Post Edited (zufus) : 4/4/2012 6:39:06 AM (GMT-6)