What is sad, that no only you or many PC patients but some doctors think that Provenge doesn't work and use Media and other unscientific sources ( for example financial situation ) for justifying their believes. Some prominent doctors like Dr. D. Petrylak said so many doctors come to him and use reason not to use Provenge like "Huber false theory", it is concern him and shame and unfortunately that this paper was even excepted.
It is unacceptable. What is acceptable - scientific evidence ! True - Provenge showed overall survival (OS). The only drug in PreCHEMO space that prolong survivor. No one drug, no Zytiga, no HT, no Xtandi yet showed OS in this space. ONLY PROVENGE.
Everybody expect miracle from Provenge and when it didn't happened that conclusion- Provenge does not work. No body expect miracle from Zytiga, Chemo, Xtandi and other drugs.
You said your father benefit from Zytiga. It is wonderfull ! But remember many patients didn't response to Zytiga too. You can read about
it on this website or others. For example:
" David Lawrence, on August 27, 2013 at 11:30 am said:
Interesting stuff.I followed docetaxel with abiraterone and prednisolone. My PSA lept to 500+ ng/ml. I then came off everything for a couple of months, and my PSA came down to 28 ng/ml. I then moved to enzalutamide + prednisolone and over the last 6 months my PSA has crept up to 220 ng/ml again. My doctors are talking about
putting me back on docetaxel!
It’s a confusing life. … By the way, I have refused to go back to docetaxel. … I am not going to suffer that loss of quality of life again."
It was patient response to the article about
cross-resistance between Zytiga and Xtandi. It is why many doctors recommend to use sequences of drugs with different MOA.prostatecancerinfolink.net/2013/08/26/abiraterone-acetate-or-enzalutamide-first-it-seems-to-matter-for-some-patients/#comments
So many patients who use Provenge also benefit from it .
Remember no biomarkers yet for immunotherapy, old biomarkers ( as PSA) don't work. Don't forget all patients are mHRPC.
It means median life expectancy for them 36 months. Goal - EXTEND LIFE and QOL. It is no easy to show OS for drugs in HRPC.
PC patients was lucky to have so many new drugs in last 3 years. We don't now how often other new drugs will come.
Remember just recently Takeda announces unbinding of Phase 3 Study of TAK-700 in mHRPC patients after Chemo because TAK-700 would likely not meet the primary endpoint of improved OS. It will be even more difficult for them show OS in prechemo
But come beck to Provenge. You said "I struggle to find more than a few who have actually seen real success."
So many of them on this MB, I posted several links, you can read about
them on company's website and on Provenge's website.
You said " Yes my father feels better, but if no effect is evident from the cancer itself I find it hard to think of it as making a major impact."
Remember no biomarkers yet for immunotherapy, old biomarkers ( as PSA) don't work.
You said "... The Dr and I think the good scan report is more the benefit of the 14 months on Zytiga than the Provenge"
Your father 9 months after Provenge treatment and the inhibitory effect keeps accumulating over time. So I belive it can contribute to Provenge. PROVENGE treat cancer, other drugs like ZYTIGA, Xtandi treat symptoms (PSA redaction?). Other therapies have a benefit that disappears when the therapy stops but that Provenge will remain in patients body for an extremely long time, maybe the rest of their lives.
repeated information: In my country where I am from, we have proverb "Repetition is the mother of knowledge."
So I repeat again: "Dr. Freedland compared this to a runaway train going over a broken bridge, i.e. immunotherapy is going to slow this train down, but it is never going to stop the train or reverse the train. Therefore, the earlier you treat with immunotherapy, the better it is...treat aggressively to get as many agents in as
It is sad that patients need to be mHRPC to receive Provenge. Who knows maybe we can cure or make it chronic decease if give early. Right Devasted1 ?
Sometimes FDA approve drug without result from trial like this:" On July 20, 2012, the U.S. Food and Drug Administration (FDA) granted accelerated approval of Kyprolis® (carfilzomib) for Injection for the treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent (IMiD), and have demonstrated disease progression on or within 60 days of completion of the last therapy. Approval was based on response rate.
Clinical benefit, such as improvement in survival or symptoms, has not been verified."
Immunotherapy and special when it personalize for each patients like Provenge is future for cancer.
It is why vaccine immunotherapies are being tested in more than 600 clinical trials as treatments for many of the cancers . Just 2 days ago on 08/26/2013 AstraZeneca took a further step to bolster its pipeline of new cancer drugs Monday by agreeing to acquire privately held U.S. biotech company Amplimmune. It's product line-up includes AMP-514, an anti-programmed cell death 1, or PD-1, medicine that is expected to ready for testing in patients later this year.
So big farma know what a gem is immunotherapy.
But it is also no easy. A lot of them fail. The closest immunotherapy to Provenge: Yervoy ( result could be known 2015) and Prostvac ( maybe 2016). We don't know if they are successful or if successful they will be better then Provenge.
And last you said "...there financial situation is a disaster about
It is difficult to tell why only 3 000 patients last year were treated with Provenge and maybe the same number this year. about
60 000 HRPC patients diagnose every year and if even 50 % of them refuse to take Provenge ( they don't believe like you or doctors don't believe , or they progress so quick that no reason give them it, even when majority of patients with mCRPC will be asymptomatic when initially diagnosed ) it is still 30 000 that could benefit from this treatment.
Is some "Forces" interesting to make company to go in the bankruptcy and put this drug on the shelf ? or maybe management ( new CEO and his team come to company just 2 years ago) of company interesting take it private, so they need sabotage sell of this drug ? Why so many drama around Provenge? I don't know answer. Who behind of it ? WHO bring this new team to the company? Where PCF
with all its money and no words from them about
this treatment and no effort to educate patients ? Are Milken and his friends behind those "Forces" to destroy Provenge and they are busy to fill up they pockets then save patients ? Here my opportunity to say my BIG THANKS to Malecare Prostate Cancer Support , personal Joel T. Nowak, Malecare’s Director of Advocacy and others who try to educate PC patients about Provenge .advancedprostatecancer.net/ Bottom line is "...on the other hand, you treat a population of men in this way and they live longer than the population of men not treated in this way... "
( Dr. O. Sartor, you can read his opinion about
Provenge in my post 2/4/2013 ).
And last the most important is your father had Provenge and will no look back for missed opportunity like thousands other patients. And when he move to other drugs and respond to them or just continue to live his life think about
that maybe Provenge that still inside him is working every day and every hours probably for the rest of his life.
My best to you and your father " I have learned that there are things in this world that I can not change, but I can embrace them and accept them as they make up who I am." (Joel T. Nowak}
Post Edited (HOPENEVERDIE) : 8/29/2013 6:02:00 AM (GMT-6)