TriMix Question for TriMix Users???

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hotrod58
Regular Member


Date Joined Sep 2012
Total Posts : 36
   Posted 9/16/2012 10:52 PM (GMT -7)   
Greetings All:
Well, got my TriMix from Mayo Clinic and tried it. My initial prescribed dose was 0.1 ml. Now keep in mine my needles are insulin syringes that also list units as measurements. First tries 10 units which equals my prescribed dose of 0.1ml, very poor results to say the least. Last night I tried approximately 13 units, not good results, no stained erection, just a brief "Chubbie" that was not usable and did not last long. Getting frustrated since my instructions from Mayo say not to exceed 0.7ml. Am I reading this needle wrong and not getting enough TriMix? Can someone please give me some advice in this matter as I'm getting frustrated that med not doing it's thing. Can you also explain this ml versus units scale on needle? Lastly, is this a trial and error thing with doses and how high can I go without "Mr. Winky" getting in trouble?? Shots no problem, just getting poor results is sooo frustrating as this TriMix is not cheap also. I even thought I may have got a bad batch of med? By the way, my needles are: BD U100 Insulin Syringes if that helps?

THANKS in advance to you TriMix users that can advise.

Regards: Hotrod58

Post Edited (hotrod58) : 9/16/2012 11:55:10 PM (GMT-6)


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4774
   Posted 9/17/2012 5:01 AM (GMT -7)   
Sounds like you're reading the needle correctly. Are you injecting in the middle and or towards the base of the penis?

There are all sorts of video and pics on the proper way to inject which can make all the difference in the world.

Stay tuned as I'm sure someone will come along and share links to the videos.

RCS
Veteran Member


Date Joined Dec 2009
Total Posts : 1232
   Posted 9/17/2012 5:48 AM (GMT -7)   
I am a bit surprised the Mayo Clinic did not have you get the first injection in their offices; however having said that it sounds like you are doing most things right, and that all you have to do is keep increasing your dosage ... slowly. It's a good sign that you are getting a chubby. Last thing you want is an erection that causes you a trip to the ER.

You may want to go to the following link. I think it pretty much answers all of your questions.

http://www.ustoo.org/PDFs/Injection.pdf
PSA 2007 - 2.8; 11/24/2008 - 7.6; PCa Dx 2/11/09; age at Dx 62; RLP 4/20/09
Biopsy - Invasive moderately differentiated prostatic andenocarconoma; G 3+3=6; PT2C; No evidence of Seminal Vesicle or Extraprostatic Involvement; Margins clear; Tumor identified in sections from prostatic apex. 70 gram prostate. Continent after removal of cath.
ED - Trimix works well; levitra @ 90%
PSA - <0.1, 8/10/11

trimix
Regular Member


Date Joined Oct 2011
Total Posts : 399
   Posted 9/17/2012 5:54 AM (GMT -7)   
Hi Hotrod- You are certainly reading the syringe correctly....My Uro wanted me to start at 1cc (100 units) and gave me preloaded syringes at first for my trial period.

After reading about the 4 plus hr erections on this site and also "Franktalk.org" and trips to the ER to get "Willy" to finally relax, I took it upon myself to back it down to .25 cc and work up slowly to what works well.

You if you are injecting in the "sweet spot" as the videos will show you then you are on the right track. Move up the amount of your injection very slowly until you get a good hour before willy collapses from excitement.

With some guy's just a little difference in the volume of trimix can make a very big....change in how long your erection will stay with you, seems that some guy's are really sensitive to the amount it takes.

For me, I slowly worked up to .5 cc, also using insulin syringes. That amount worked very well for me and over time, the trimix has giving me some really good rehab.....I have now been able to move back down to .25 cc with the same results...

Good luck, lets us know how you are doing....

Cheers,

Curt
PSA: 5/05-2.008, 12/08-2.87, 2/11-4.357
3/11- 12 needle biopsy, 1 core positive GS 3+3
5/3/11- RP performed, tumor volume 1cc, pT2c all margins and lymph nodes negative
PSA: 8/1/11-.06, 10/26/11-.16, 10/31/11-.17, 10/31/11-.19
11/24/11- Started for 22 days
PSA: 12/16/11- .154 Stopped Avodart
12/22/11 Started Trimix
PSA: 3/12/12- .157
PSA: 6/12/12- < .1 :-)
Age 61

PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5638
   Posted 9/17/2012 7:41 AM (GMT -7)   
It is worth mentioning that there isn't any universal standard for how much of which drugs are in each cc of "Trimix". Different urologists and different pharmacies use different strengths. This makes it difficult to compare dosages with other forum members. In addition to the standard "all men respond differently" caveat, you also have to factor in the concentration of the drugs when you talk about how many "units" you use.

My current bottle of Trimix is approximately half the concentration that most other Trimix aficionados here use (so I get the same amount of drug from 40 units that they get from 20).

That said, it doesn't sound like you are injecting a lot. The usual range for my (rather watery) mix is 20 to 50 units and I seem to do well in the 35 to 40 unit range. Assuming your mix is twice as strong as mine that would give a range of 10 to 25 units.
59
gradual PSA rise 2007-2012 from 1.4 to 8
four biopsies 2010-2012:
1)negative (inflammation observed),
2)negative,
3)positive in one of 14 cores GS6(3+3) 3-4%, 2nd opinion gs7(3+4)
4)negative.
DaVinci RRP 6/14/2012
positive margins in apex and 1mm margin in base. GS9(4+5)
Started 24 mo ADT (Triple w/ Lupron) 7/26/12
sched for adjuvant radiation therapy

hotrod58
Regular Member


Date Joined Sep 2012
Total Posts : 36
   Posted 9/19/2012 10:37 PM (GMT -7)   
Greetings All:

My TriMix from Mayo Clinic is: Papaverine: 18mg, Phentolamine 0.6mg: Alprostadil 6mcg. Does this seem like a "Normal" mixture, (if there is such a thing)?? I'm still working on finding what works best to get an erection, not there yet.

Regards: Hotrod58

Jstars
Regular Member


Date Joined Oct 2005
Total Posts : 487
   Posted 9/20/2012 6:35 AM (GMT -7)   
hot-r:

hotrod58 said...
My TriMix from Mayo Clinic is: Papaverine: 18mg, Phentolamine 0.6mg: Alprostadil 6mcg.


Now we are talking apples to apples .. good.

I think a 'Standard' Trimix prescription would be 30mg Pap, 1mg Phent and 10mcg PGE-1. And even that is not too strong.

A 30mg 1mg 20mg might be called Super Trimix. They go all the way up to 40mcg or more PGE-1 though so I dunno what those version might be nicknamed ... "To The Moon Trimix" ??

So bottom line is you have a very weak solution and will no doubt you will use quite a bit more before you see Results. This assumes you are sticking it into the CorpusC OK. You will see various discussions here (and on Franktalk.org) about how to tell if you are hitting the CC. When done with this vial definitely ask your Mayo guy for at least the Standard script -- after all you are paying the same amount usually no matter what the strength -- if you can stand higher PGE-1 with no ache then you should demand stronger scripts -- so you get many more shots for your money.

Good luck, keep on trying, AND while you are just finding your proper amount it is OK to try once a day (or even once in the AM and once in the PM) so that you can start Dancing with your partner as soon as possible. After that you can settle in to 2 or 3 times a week (whether you need it or not!).

J

142
Forum Moderator


Date Joined Jan 2010
Total Posts : 6746
   Posted 9/20/2012 7:56 AM (GMT -7)   
And remember to shake it well before use (the vial devil )
 
I go from a one hour 100% at .11 to a four hour headed to the ER 100+% at .13. A little bit can make quite a difference.

Venguy
New Member


Date Joined Sep 2012
Total Posts : 5
   Posted 9/28/2012 10:55 PM (GMT -7)   

Hi:

I leave in Venezuela and I am new on injections. Cialis, Viagra and any other kind of pills definitely donĀ“t work for me. I have had once a .02 ml of trimix and work just a bit; but much better than anything else before. It was a spare of a friend of mine and has not been able to find any more over here

My question is: Could it be possible to get it send safely to Venezuela without been degraded? Which lab should contact to? Please

59 Years

Prostate Cancer diagnosed Nov. 16, 2010

Biopsy 11/01/2010 Gleason score = 3+4=7

Radical Prostatectomy on 2/2/2011

Pathology - negative margins from successful surgery

5 mg Cilias daily for 6 month

Almost no leakage after 5 weeks

Not Having been able to have an erection yet.

Just a bit with try of Trimix, no pain

 


PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5638
   Posted 10/2/2012 11:50 AM (GMT -7)   
Andean,

The reason nobody answered your question is because the question is difficult.

Trimix is a prescription medicine (at least in the US, Canada, UK, etc., I don't know about Venezuela) and the first step in your getting access to it is to talk to your doctor. He probably knows where his other patients get it and he can give you some advice (and instructions on how much to use and how to inject it.)

Once you get a doctor's prescription, there are pharmacies that ship Trimix packed in ice. They could probably get it to Venezuela but the shipping would be expensive.

Good luck

Post Edited (PeterDisAbelard) : 10/2/2012 3:25:39 PM (GMT-6)


142
Forum Moderator


Date Joined Jan 2010
Total Posts : 6746
   Posted 10/2/2012 12:06 PM (GMT -7)   
Agreed - the logistics of shipping would be difficult (to Venezuela) when considering customs clearing time. The biggest issue would be getting a prescription valid in the US to get to the compounding pharmacy.
 
I don't have any specific contacts, but I would look for a compounding pharmacy in Miami, Florida, thinking that shipping would be most direct from there, and they might have international payment arrangements.
Moderator - Prostate Cancer
(Not a medical professional)

DaVinci 10/2009
My adjuvant IGRT journey (2010) -
www.healingwell.com/community/default.aspx?f=35&m=1756808

Mrwyo
New Member


Date Joined Jan 2015
Total Posts : 1
   Posted 1/31/2015 7:18 PM (GMT -7)   
Hi,
I'm new to this forum. I'm new to this forum and appreciate any advice anyone can give.
I have had a prostate biopsy, no cancer and a new test (methylization?) said it was not likely. But ED for some time. Viagra and Cialis worked for some time and then quit. Some herbal preparations worked even after Viagra, but have failed.
I'm now starting injections with Trimix. My prescription is Papa 30 mg, phenyl .2 mg, alp 10 mcg. Cost was $110 for 5ml + $40 shipping from Denver.
My first injection of 2.5 ml was not successful and doctor said next one will be 3.5.
My questions: Is this reasonable? Also, my tummy is large enough that seeing that is impossible and I wonder if anybody else has advice.
Thanks

PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5638
   Posted 1/31/2015 8:47 PM (GMT -7)   
Mr Wyo,

I've started a new thread for you so members can see your questions and have taken a stab at some answers myself.

Here's a link to your thread: Welcome new member: Mrwyo
62
Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012:
1)neg
2)neg,
3)positive 1 of 14 GS6(3+3) 3-4%, 2nd opinion GS7(3+4)
4)neg.
Mild Pre-op ED
DaVinci RRP 6/14/12. left nerve spared
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12
Incontinent, Trimix, VED, (AUS Planned)
Forum Moderator - Not a Medical Professional

DanLaurence
New Member


Date Joined Nov 2015
Total Posts : 5
   Posted 12/16/2015 1:51 AM (GMT -7)   
Trimix dose and how one can equate the fluid volume of for example .15 cc to a visual such as eye drops or better yet the % of a teaspoon?

I expect to begin Trimix next week after I have my follow up visit with my Urologist and the Rx is issued to the Compounding Pharmacy. I'm confident my Doctor or his RN will explain the key points, yet I like to gain all the possibly information and details by reading and researching a drug. The use and injections I totally comprehend, yet the ability to equate the dose such as .15 cc seems to escape me.
My take this far is that .15 cc is only a small liquid volume and presume that it's actually equivalent to a few eye drops or less than 1/8 a teaspoon. When I read about "Units vs CC" I'm lost!
Then I see posting on the forum where participants mention increasing the dose to .50 cc, which of course is a higher fraction and it's a higher dose etc...

The best I'v been able to comprehend about 5 ML Vial @ .15 cc doses, that a patient can have Qty 33 injections, with use 2/3 times per week, that number sure offers an excellent unit injection cost factor!
So the reason I'd like to figure out the averages of Rx, Vial, Dose and cost would sure be helpful. Thus I figured knowledgeable users could offer meaningful insights.

In either case my intent is to go forward and have only positive expectations, since my Urologist is an exemplary Doctor, yet I respect his time and avoid getting into aspects his RN and ultimately the new Pharmacy can address once the Rx is issued during my visit on Friday.
Appreciate feedback! Daniel

PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5638
   Posted 12/16/2015 8:41 AM (GMT -7)   
Dan,

A drop from an eye dropper is very approximately 0.05ml = 0.05cc. So your 0.15 dose would be about three drops. Like you said, your 5ml vial will give you 33 0.15ml doses (if 0.15 turns out to be what you need -- some guys need more). If trimix came in 2 liter bottles like Cola you would get 13,333 0.15ml doses per bottle which would last you 85 years at three injections a week. In theory, once mixed the drugs are only good for a few months in the refrigerator but if you froze it in liquid nitrogen it might make 85 years. But it's probably better to just buy another vial every two months or so since keeping a dewer topped up with liquid nitrogen is a chore.

You'll do fine.
62 Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012: 1&2 neg, 3 pos 1/14 6(3+3) 3-4% (2nd opn. 7(3+4)), 4 neg
DaVinci 6/14/12. "some" nerve sparing on left
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adj IMRT 66.6 Gy 10/17/12-12/13/12
8/2012-3/2015: Incont., Trimix, VED, PSA<0.015.
AUS & IPP installed 3/5/2015
Forum Moderator - Not a medical professional

DanLaurence
New Member


Date Joined Nov 2015
Total Posts : 5
   Posted 12/16/2015 10:30 AM (GMT -7)   
"Mrwyo"
I'v posted this reply in the forum since I was unable to give a thread response. Yet hope this is a very helpful resource for those searching for a good Compounding Pharmacy.

I actually identified this Pharmacy on HeelingWell.com and they have an impressive Website;
University Compounding Pharmacy -
UCP - San Diego, CA (see Website + U-tube video) there focus is on Compounding, with a 100% clean room environment. They ship overnight cost included, 5 ML Avg Rx $120/145 (range is basic strength to high & 10 ML offer better shot cost ratio). I email Customer Service and get professional response with 24hrs. My first Rx will be filled next week!

FYI, I live in Fresno, CA with population of 500K, have an excellent Urologist, excellent Medical Facilities with 3 compounding pharmacies and only one does Trimix, with prices which are $57/95 higher then pharmacies outside Fresno. Kaiser does in-hospital compounding but it's Kaiser members only, therefore I'v selected University Compounding, at presents good credentials that I look for in all medical related selections...
Hope it's helpful insight.
DLBLaurence@gamail.com

Home Depot
New Member


Date Joined Nov 2017
Total Posts : 5
   Posted 11/7/2017 9:36 PM (GMT -7)   
i'm in my 80s and will be trying trimix for the first time tomorrow
the DR wants to start me with 2.5 for my first dose, does that seem right?

avidtom

PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5638
   Posted 11/7/2017 11:48 PM (GMT -7)   
Avid,

Welcome to the forum. Hope we can help.

In general you should follow your doctors instructions.

But, beyond that I get a bit vague about your question. 2.5 what? Usually the vial will hold 5.0ml and most guys get many jabs (something like 20) from each vial.
63 Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012: 1&2 neg, 3 pos 1/14 6(3+3) 3-4% (2nd opn. 7(3+4)), 4 neg
DaVinci 6/14/12. "some" nerve sparing on left
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adj IMRT 66.6 Gy 10/17/12-12/13/12
8/2012-3/2015: Incont., Trimix, VED, PSA<0.015.
AUS & IPP installed 3/5/2015
Forum Moderator - Not a medical professional

Home Depot
New Member


Date Joined Nov 2017
Total Posts : 5
   Posted 11/8/2017 1:31 AM (GMT -7)   
the mix ispge-1 =10mcg phentolamine = 1mg papaverine =30mg 5 ml vile

from this I draw 2.5 mg

avid

PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5638
   Posted 11/8/2017 8:06 AM (GMT -7)   
avid,

Thanks for the clarification of the dose you are using. That is a fairly standard mix. Your doctor should have described how to slowly adjust your dosage -- starting fairly low and using a bit more each time you inject until you find the right dose -- and if you find that it takes a lot to get there you should ask your doctor about a stronger mix.

I'm still confused about how much you are to inject. Usually trimix is injected using an insulin syringe with a small gauge needle. Insulin syringes are marked with "units" where each unit is 1/100th of a milliliter. Some syringes will hold half a ml and are marked with 50 units. Other syringes hold a full ml and are marked with 100 units. Right off the top of my head the usual amount guys inject with a mix like yours will range from 10 units (0.1 ml) to 70 or so (0.7 ml approx) depending on how strongly they react. I suspect your doctor said (or meant to say) 25 units which would be 0.25 ml (about 1/20th of your 5ml vial.)
63 Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012: 1&2 neg, 3 pos 1/14 6(3+3) 3-4% (2nd opn. 7(3+4)), 4 neg
DaVinci 6/14/12. "some" nerve sparing on left
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adj IMRT 66.6 Gy 10/17/12-12/13/12
8/2012-3/2015: Incont., Trimix, VED, PSA<0.015.
AUS & IPP installed 3/5/2015
Forum Moderator - Not a medical professional

Home Depot
New Member


Date Joined Nov 2017
Total Posts : 5
   Posted 11/9/2017 2:59 AM (GMT -7)   
Sorry for the confusion the dose is 25 units everything went OK today I gave my own shot,
Started at 20 units which was about 75% of what I needed,will go to 25 units next time.
No pain at the injection site but some pain at the end of my penis , lasted about 3 hours.
totally flaccid in 4 hours.
Can you give me an idea of the cost of trimix of a 5 ml vial?

regards avid

Home Depot
New Member


Date Joined Nov 2017
Total Posts : 5
   Posted 11/9/2017 5:40 PM (GMT -7)   
Is there a preferred site to put the injection in?

Are you better off to put the injections as close to the base as possible?

regards avid

RCS
Veteran Member


Date Joined Dec 2009
Total Posts : 1232
   Posted 11/9/2017 6:21 PM (GMT -7)   
This may show you where to inject ..... and answer other questions:

www.ustoo.org/PDFs/Injection.pdf

PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5638
   Posted 11/9/2017 9:33 PM (GMT -7)   
Avid,

The cost sort of depends where you buy it. You need to get it from a "compounding" pharmacy because, in theory, it is a custom formula made from directions in your doctors prescription. In most cases I think all the compounding pharmacy does is to add water to dissolve the powdered drugs their supplier already put in the vial. But you need to get it from a special kind of pharmacy and there are only a few such in most communities. So local competition on price is limited. But there are a few online pharmacies that will ship trimix packaged with cold packs which may have better prices.

My local compounding pharmacy sold the "watery starter mix" you are using for about $145 per 5 ml vial. If your magic dose turns out to be 25 units then your cost per jab at that price would be $7.25. I eventually graduated to trimix "super" that was slightly more than two times as strong and sold for $155 per vial.
63 Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012: 1&2 neg, 3 pos 1/14 6(3+3) 3-4% (2nd opn. 7(3+4)), 4 neg
DaVinci 6/14/12. "some" nerve sparing on left
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adj IMRT 66.6 Gy 10/17/12-12/13/12
8/2012-3/2015: Incont., Trimix, VED, PSA<0.015.
AUS & IPP installed 3/5/2015
Forum Moderator - Not a medical professional
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