I just got back from my monthly onco consultation. My PSA rose a point in the last few months, but more significantly, my testoterone more than doubles to nearly 60. On top of everything else, I tested positive for the BRCA2 gene mutation which may have caused the cancer.
For the past year, since diagnosis, I've been on a combo of Lupron and Casodex. As a result of the testoterone rise, he wants to take me off the casodex for a bit and see if that has any influence.
I didn't discuss it took much with him, but can anyone explain how taking me off the casodex would caused the testosterone and the PSA to go down? It seems counter-intuitive since casodex is supposed to block testosterone reception by the cancer cells.
Does anyone who has been on ADT2 espeically with casodex ever fight a rising PSA by stopping the casodex and if so, what were the results and how long did they last? And what was done when the strategy stopped working?
Diagnosed 9/14/2011; Age 47; PSA 5,000+
Metastatic Stage 4, spread to entire skeleton w/femur fracture
Current therapy: Lupron/Casodex/Aredia
June 4, 2012: PSA 2.2, doing well with little discomfort
June 27, 2012: PSA 1.42
July 24, 2012: PSA 0.69 !!!!!
September 25, 2012: PSA 1.2 (Oops)
October 11, 2012 PSA 1.4 (not good)
Post Edited (JohnKeats) : 10/22/2012 11:47:02 AM (GMT-6)