I've been on ADT3 for five months now, more or less, and my brain is a mess. You've probably noticed...
I have always been borderline ADD. I have trouble aiming my mighty brain at any target as small as, say, work
and I compensate for that by being smarter than most people so that the little time I can manage with my brain on target produces enough effect to keep my employer happy.
Just lately my percentage of time on target has dropped drastically, the drop coinciding nicely with my ADT3 treatments.
I got to wondering why this might be and found a couple of studies.
Here they are: Impact of Androgen-Deprivation Therapy on Cognitive Function in Men With Nonmetastatic Prostate CancerEffects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis
The first study rounded up three groups, men with PCa who are on ADT, men with PCa who are not on ADT, and healthy control men of about
the same age -- about
eighty of each. They then gave all three groups a bunch of cognitive function tests and found that after six months of ADT the ADT guys, the PCa guys and the controls all scored about
Shabbir M.H. Alibhai, MD, et al. said...
12 months of ADT use is not associated with adverse effects on objective measures of cognitive function in middle-aged and older men. These results should be reassuring to clinicians and their patients with PC who require ADT to help control their disease and prolong survival.
I must confess that I am less reassured by this than they suggest I should be. If my vagueness is caused by the ADT then I can hope that it will improve when I stop the Lupron. Otherwise, I am becoming senile.
I like the other study better. It also did more or less the same cognitive function tests and it also found no significant difference in performance. But they also did fMRI brain scans of the men while they were performing those tests and found that the brain activation levels in the ADT men were much lower than the controls. Here's that image
They also looked at changes in the resting state functional connectivity and found significant decreases in the ADT group that weren't in the controls and were all on the right side of the brain
. Here's that image.
Now we're talking: It's not all in my head! It's all ... umm... in my head.
Slow PSA rise 2007-2012: 1.4=>8
4 biopsies 2010-2012:
1)neg (inflammation observed),
3)positive one of 14 cores GS6(3+3) 3-4%, 2nd opinion GS7(3+4)
Moderate Pre-op ED
DaVinci RRP 6/14/12. left nerve spared
Post-op path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
Start 24 mo ADT (Triple w/ Lupron) 7/26/12
Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12
Incontinent, Trimix, VED for Rehab