a discount, worthless, s.w.a.g., truly conjecture guess based upon thin air???? Maybe since this drug is Enzalutimide and in the flutamide family line (bicalutamide, flutamide, nilutamide) all the casodex relatives just mentioned, and Xtandi-Enzalutamide also sometimes called 'super casodex' by some circles. Thus another one of them, just known to bind better to the AR receptor, thus a better casodex in effect.
Thus, my conjecture based upon s.w.a.g (guess) is it is that the AR receptor just like in casodex occurrances, is not binding to the AR receptor, thus not working anymore at this juncture. Now if that is true perhaps going off of it you might get AAWD (anti-androgen withdrawal)???? If so, perhaps going off of it now could show a drop in psa, as strange as that sounds....it can happen with casodex and this is known. In some patients whom experience fast psa increases while on casodex, the casodex phenomena was feeding the PCa and when they went off of it and tested psa soon enough thereafter saw the AAWD, a psa drop. You can google and read about
AAWD so you understand this weird phenomena. Is PCa complex and strange enough???
Dr. Sawyers co-inventor on this drug, said he thought ARN-509 he invented might even be better, but in the same family, also. No doubt I will be interested in seeing more on this question, it is an interesting question.
see website www.hrpca.org (you might have a response on things like leukine, emcyt, DES, thalidomide-aka Revlimid, sangiostatin, alpharadin, samarium, strontium, maybe Jevtana, just ideas)
Post Edited (zufus) : 12/23/2012 6:24:36 PM (GMT-7)