I read this study a
while ago. I think what it is really
saying is that G6 does not appear to metastasize to “lymph nodes”. If
that is the case, then the only other way it could metastasize would be through
the circulatory system. Since, they don’t
know this to be the case for sure, I don’t believe they are saying that G6 does
not ever metastasize. But, since they were unable to find even a single
case of it metastasizing to the lymphatic system in 14,000 patients, and that’s
good enough for me, then it would also be highly unlikely that it
would spread through the circulatory system either. I would imagine the same component needed for
G6 cells to break away into the lymphatic system would also be required for it
to break away into the circulatory system.
In other words, G6 tumors seem to stay intact and individual cells don’t
seem to break away from the primary tumor.
So, what does this mean
in regards to treatment…..
First, keep in mind that
there is no way to tell if someone is truly a G6 unless you take their prostate
out and examine it.
So, consider these
(G6 does not metastasize,
G6 WILL TURN into a more aggressive cancer that does metastasize)
If this is true then you
could conclude that if you catch your PCa at the G6 stage and you treat it then
you have truly caught it during the “window” of curability.
(G6 does not
metastasize, G6 WILL NOT turn into a
more aggressive cancer)
If this scenario is true
then you could treat G6 with minimal intervention or not treat it at all
depending on what it does inside your prostate.
But, again you would have to have some way to know without having
surgery that 100% of your cancer is G6.
There is no way to do this right now.
Either way, right now
there is no way to tell if you are 100% G6 without removing you prostate and
there is no way to tell for sure whether or not G6 will one day mutate to a
more aggressive form of PCa. Until then
I think if you are young enough and don’t like to gamble, you have to
treat. I feel very strongly that G6
probably does not metastasize, but who knows if over time that it won’t mutate into
a more aggressive cancer. So, right now I would live by the first scenario
and believe I caught it when it was “curable” in the form of G6.
By the way this was
actually a Johns Hopkins study….. here is the link.