Down the rabbit hole!
From what I've been able to gather the side effects are mainly from having your testosterone wiped out, not from the Lupron itself. The various testosterone vs. time graphs from Abbot Labs look pretty similar. Once it's down at the target castrate (sigh....) levels, it just stays there no matter what dosing pattern you use. A larger question is what if it doesn't hold there near the end of the 6 month period? The literature says it stays down for the whole time, though. IDK...
The shorter time-period doses seem to allow ending the treatment period at some specific point. If you only need T held down for 3 more months, then take the 3 month shot, for instance.
Also, my insurance will NOT pay for the next injection until the absolutely full time period has elapsed. The doc's office said they'll deny coverage if you're even one day early. My next one is at 6 months, plus a couple of days since that made it on a Monday. It was billed at $500/mo, and $3000 for 6 months, so financially it didn't seem to matter. Astounding - $3000 for a thimbleful of white fluid! Bat wings and eye of newt must be pretty precious nowadays....
Others have said they like the one month version because they can see the doctor more often that way. That wouldn't really work for my doc's office; one of his assistants administers the injection. To see the doctor, one makes an appointment with him specifically.
It seems prudent to get a 1 month shot, after 4 weeks verify your T levels and PSA are dropping as expected, then go for the longer-term injection. Not everyone responds the same to these things, and there are other similar compounds for the same purpose.
On the off chance you're as geeky about
this stuff as I am, here's a link to the one-month info sheet with more than you ever wanted to know about
Lupron (graph on page 4):
And the 3-4-6 months info sheet (graphs start on page 26):
IGRT by IMRT started 6/26/13: 50.4 Gy pelvic nodes, 79.2 Gy prostate
ADT2: Lupron 5/1/13 (2 yrs)+Casodex 6/25/13 (1 yr? 2?)
Age 55 @ Dx 4/16/13 -
Bx w/12, one side all G9=5+4 (80%, 60%), 4+5 (2 at 100%, 80%, 10%), PNI confirmed
3T MRI: Bilateral EPE, NVB+, SV-, LN-, staged cT3
Date PSA fPSA
3/13 5.2 12% PCA3=31
9/12 4.1 15%
history... since 2002 high/varying PSAs, w/3 neg bx
Post Edited (Redwing57) : 8/10/2013 6:17:15 AM (GMT-6)