Sand Lake Imaging published some results of their trial of Feraheme (ferumoxytol) as a contrast agent for revealing lymph node mets. Based on 136 men, the technique detected 74 positive lymph nodes, 90% of which were positive on biopsy. about
half of those would have been detected using standard imaging techniques. They detected tumors as small as 3-4 mm, which is much better than the 8 mm detection limit for C11 Choline PET scans.
Unfortunately, they seemingly did not biopsy lymph nodes that tested negative
with Feraheme, so it is impossible to say what % of all cancerous lymph nodes were revealed (sensitivity).Safety and Efficacy of Ferumoxytol as a Lymphatic Contrast Agent
Dr. Barentsz of Radboud U in Nijmegen, The Netherlands has re-applied to the FDA for approval for the use of such contrast agents for metastatic lymph node detection. The leading US researcher on their use has been Dr.Harisinghani at Mass General.