Thanks so much Casper319 and Oncas for your responses! Greatly appreciate this information. Each case is so unique -so hard to make sense of how everyone responds so differently to the medications.
Casper319- just curious why you are on Xofigo if your PSA was going down from Zytiga. Are you taking both at the same time now or did you go off Zytiga?
Oncas -you do present a very interesting condition as you mentioned with a low PSA but bone mets. This disease is so perplexing!
Just to recap where my Dad is - he was initially diagnosed in 2001 and had RP in the Fall at that time. I don't have the details on his gleason score and such, but cancer was supposedly confined to prostate, caught relatively "early" and removed. He was treated with radiation after surgery and then on hormone therapy. He enjoyed 10 years of remission (we never thought about recurrence), always went to the doctor, etc. This past April during his PSA check -it was found at 16, scans revealed bone mets. A Lupron shot was given, PSA went back to 12. He did Provenge from late May-early July. PSA rose to 60 during that time and back pain became pronounced after Provenge. He started Zytiga/Prednisone in mid August. First result after being on it after 2-3 weeks was PSA dropped from 60 to 20. Most recent result showed a rise to 30. Didn't think it would stop working so quickly but not sure if it is too early too tell. He's going to MD Anderson later this week to see what they recommend. Will have first scans done several months post Provenge so will be interesting to see what they look like. His back pain has improved considerably since starting on Zytiga -remains very active -not debilitating, etc. His doctor in Chicago is suggesting Xofigo.