I have low testosterone and low PSA, and had a Gleason 9. I'm back on T supplementation after my RRP. Dr Mulhall makes a good case for T replacement therapy post RRP in men with low testosterone! I've been on T for a awhile post RRP and my latest PSA < .01 (see below)
My total and free testosterone, at least in recent years, has run at very low normal levels, just above what would be considered below the normal range. In fact, it was while seeking possible testosterone therapy that I got the PSA done which ended up with me diagnosed with a G9 PC.
My friend here in town, who had his RALP a few years before me, had for many years before that suffered with way below normal T, although he had also been treated with injections for a couple of years. Although probably he had low T for many years before he got any T therapy. So that is 2 I know of, plus PSA3DOT7, or a rather small study. LOL! But, kind of makes me wonder. ( BTW, my friend who had the RALP: he has been back on T injections pretty much ever since his RALP. He insists that he can not make it otherwise, can't stand a low T. So far, so good)
Dreamerboy, according to Abraham Morgentaler MD, as has been pointed out, rather than it being like he was taught- i.e. T is like feeding a hungry tumor, it is more like a drink for a thirsty tumor. IOW, we can keep eating long past when we are no longer hungry, and then repeat again shortly with another piece of dessert or snacking in front of the TV, as our waist lines attest. But most of us will not normally drink more water than is needed to quench our thirst, no matter how much water is available. The body can only make use of so much water, unlike food calories which can be stored.
Ans it seems that it takes very little T to give PC cells all the "water" they need to grow. So being low won't do much good, rather you need to be close to zero, and very few low T men are anywhere near zero. And some are thinking once you get very much above zero heading for low normal, you are already passing the point where the PC cells can not use any additional T, and doubling it from that low point( whatever exactly that low point actually is) will make no difference.
Because his peers told him he better stop giving T because he was going to feed a hidden PC, Morgentaler started doing PBx on men before he would administer T. As the years went on and the numbers grew, he found that a higher % of men in his studies, who had low T, had PC than the groups who had normal or high T. Worse, the men with the lowest T had an increased risk of more aggressive PC than those with higher T. I guess if I had been one of his patients, I would have fit into that category. At least based on Morgentaler's studies and theories, which are probably still not accepted by most Uros. But maybe if I had got that T replacement therapy like I started to 10 or 15 years ago, I would be in a better condition now?
Because normal or slightly higher T levels are a positive in so many things related to men's health, I wish some big studies would be done to clear this up. Because it might be, maybe, that those of us trying to survive PC, who also run on the low T side, would do better if we got out T on up to 700 or so. IOW, maybe we would be better of, PC wise, either with zero T or a fairly high T, but not a low T. One extreme or another, maybe? I wish we could find out for sure like right now!
PSA 9.1 102813, 10.8 ~112013, drop to 8.1 on 021214 after VitC/VitK3 50 to 1 for about
Bx on 112013 at age 64 yrs 11 months, with 5 of 12 pos with one G9, 1 PNI, T2B.
RALP with lymph nodes at Vanderbilt 021914. (nodes clear, but some seminal ves. involvement, still G9, thinks he got probably got it all by cutting wide )
Foley out 030314
JP drain out on 031014