Hey clean gene... I got a little obsessive thinking on your question and how it also related to my particular situation. You wanted to know if you were "cured". Here is something I think you'll find quite comforting.
Projection of 15-year prostate cancer-specific survival after radical prostatectomy
Posted on January 21, 2011 by Sitemaster
For several years we have been able to use the Kattan nomograms to project 5-, 7-, and 10-year recurrence-free survival before and after radical prostatectomy for localized prostate cancer, based on the patient’s age, stage, Gleason score, and other relevant data (associated with biopsy or surgical findings, as appropriate).
In a new paper, just published on line in the Journal of Urology, Eggener et al. have now published data that will help us to be able to predict 15-year disease-specific survival in men undergoing radical prostatectomy for localized prostate cancer.
In the same manner as prior risk projections developed by Kattan and his colleagues, this set of projections is based on a sophisticated risk regression analysis modeled using clinical, pathological, and long-term outcomes data from 11,521 patients treated by radical prostatectomy at four major academic centers between 1987 and 2005. The model was then validated using similar data on 12,389 other patients treated at a separate institution during the same time period. The average (median) follow-up of the real patients in the modeling cohort was 56 months (nearly 5 years) and 96 months (8 years) in the validation cohort.
Eggener et al. were able to show that:
Overall 15-year prostate cancer specific mortality (PCSM) in the modeling cohort was 7 percent.
Statistically significant predictors of PCSM were
Primary and secondary Gleason grade 4 or 5 (each p <0.001)
Seminal vesicle invasion (p <0.001)
Year of surgery (p = 0.002)
Only 3 of 9,557 patients (0.03 percent) with organ-confined prostate cancer and a pathological Gleason score of 6 or less actually died of prostate cancer post-surgery.
Based on these data, they have developed a nomogram that is capable of predicting 15-year PCSM which was accurate and highly discriminating when tested in the validation cohort of patients.
When patients are stratified by age at diagnosis, the nomogram predicts 15-year PCSM rates as follows:
For men with a pathological Gleason score 6 or less — 0.2 to 1.2 percent
For men with a pathological Gleason score of 3 + 4 = 7 — 4.2 to 6.5 percent
For men with a pathological Gleason score of 4 + 3 = 7 — 6.6 to 11.0 percent
For men with a pathological Gleason score of between 8 and 10 — 26.0 to 37 percent.
For men with organ-confined disease — 0.8 to 1.5 percent
For men with extraprostatic extension — 2.9 to 10.0 percent
For men with seminal vesicle invasion — 15.0 to 27.0 percent
For men with lymph node metastasis — 22.0 to 30.0 percent
The authors conclude that, “The prostate cancer specific mortality risk can be predicted with remarkable accuracy after the pathological features of prostate cancer are known” and that poorly differentiated cancer and seminal vesicle invasion are the prime determinants of PCSM after radical prostatectomy.
While it is fair to say that there are no real surprises in these data, based on cohorts of patients treated at some of the very best academic centers in the U.S.A., it will certainly add to the quality of the Kattan nomograms when these data can actually be built into the on-line prognostic tools available on the Memorial Sloan-Kettering web site.
45 at dx
PSA's: 11.7, 9.8 and 12.4
Biopsy Dx 7/29/13 Two cores 3+4 and one 3+3 no PNI
RALP da Vinci w/Nerve Sparing 8/29/13 Mayo Clinic Rochester MN
Pathology: single tumor .2x.1.x.1cm PT2n0mx downgraded to Gleason 6
Follow up PSA 12/06/13 less than 0.06 2nd PSA 3/24/14 Pending
Incontinence: No longer.
ED: Wife says I'm "85%" :) NO MEDS