Another phenomena is that there was been Gleason score inflation over past 20 years, possibly due to trial attorneys (my opinion, not the experts below).
In his most recent monthly newsletter Prostate Forum Volume 15 #10, Dr. Charles Snuffy Myers interviewed several experts including Dr. H Ballentine Carter of Johns Hopkins, Dr. Peter Carroll of UCSF, Dr. Timothy Wilt of U of MN, also lead author of PIVOT study, Dr Laurence Klotz Toronto Div of Urology Sunnybrook Health Services Centre.
Most of the discussion centered around Active Surveillance vs. Watchful Waiting vs. Surgery vs. Radiation for low risk PCa.
General concensus was that a G6 today 20 years ago would have been a 5, and so on.
65 - DX 64 2/13 PSA 3.68 (6 mo doubling) Gleason 9 (4+5)
T1CN0M1B stage IV w. 7 of 12 cores worst ones 70% right PNI
oligometastatic 5 tumors 1 right sacroiliac, 2 on
T4 & T9.
1st Lupron 4 month 3-28-13, 2nd Aug 1
PSA down was 3.68, 0.68 on 08-08-13
PSA 0.12 02-11-14, T<3,freeT<0.048
Prostate shrunk from 50.4 to 31.6
UF & Shands treating w curative intent, not just palliative.
Post Edited (LupronJim) : 4/26/2014 4:59:25 PM (GMT-6)