Thanks, that's exactly the information I couldn't find.
Actually, they did see a flare but dismissed it as "clinically" insignificant in all but four patients. Those patients were briefly bumped out of castrate levels of T but returned to castrate levels within a week. My question is whether that one-week vacation for those four guys would be enough to show as a blip on the gradual suppression of PSA. What they were worrying about
is gross symptomatic impact (pain, etc.) which sometimes (seldom) happen with a full-flown T flare in men just starting out on Lupron. Clearly that
didn't happen, which is good, but it doesn't speak to my question about
causing a bump in the PSA scores.
Since the flare only lasts a few days any flare your husband might have seen would be long over before his next bloodwork.
The study said...
Upon the transition from degarelix to leuprolide at day 90, there was a rise in testosterone from the lowest point of 16.5 ng/dl to a peak of 25.8 ng/dl recorded on day 93 (P = .0005), the researchers reported. Four patients (8.9%) experienced a clinically significant surge with a mean peak serum testosterone of 80.7 ng/dl; all four returned to castration levels within 7 days.
Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012:
1)neg (some inflammation),
3)positive 1 of 14 GS6(3+3) 3-4%, 2nd opinion GS7(3+4)
Mild Pre-op ED
DaVinci RRP 6/14/12. left nerve spared
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
Start 24 mo ADT3 7/26/12
Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12
Leaky but better, Trimix, VEDForum Moderator - Not a Medical Professional