I doubt you'll find many men whose doctors prescribed testosterone cream, and certainly not estradiol patches, to bring them back to normal levels after HT. (There is a clinical trial now to see whether it's beneficial to alternate testosterone deprivation and augmentation (called Bipolar Androgen Therapy) for some men on intermittent ADT). The reason is because supplementing testosterone will suppress one's natural production, and the first choice would be to let the body produce it naturally. Sometimes, hCG and Clomid can be used to jumpstart natural production if the hypothalamic-pituitary-testicular axis gets stuck in the off position after long-term ADT.
Estradiol patches have been shown to have much lower cardiovascular effects than the pills.
There was no "mistaken" overdose of anastrozole. You can read the full study itself (link below). The researchers were trying to differentiate the effects of testosterone from the concomitant estrogen changes that accompany it. Because estrogen is a metabolic product of testosterone, it is always present when testosterone is present, so they artificially blocked estrogen production in men while they increased their testosterone up from ADT levels. They found that small amounts of estrogen help, along with testosterone, to maintain libido and erectile function in men (small amounts of testosterone are necessary to maintain libido in women), and that it prevents fat accumulation. From other studies, we know that it prevents bone loss and is needed for thermoregulation. The study was only 16 weeks because they wanted to avoid bone loss in the subjects who were depleted of estrogen.Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men
A history of low testosterone (hypogonadism) is associated with increased risk of prostate cancer. Castrate levels of testosterone may sometimes cure it. This has been much written about
on this site, so I won't go into it here.
Post Edited (Tall Allen) : 6/5/2014 11:38:47 AM (GMT-6)