As someone who had SRT after my PSA had risen from 0.02 to 0.4 and am now, more than 4 years after SRT, getting PSA results of 0.00, here is my understanding. Prostate cancer cells are not very good at surviving outside of the prostate. To be able to travel to local areas within the prostate bed (including seminal vesicles, or local lymph nodes), it may need to mutate a bit, but not necessarily a lot. But to survive in more distant parts of the body, the PCa cells need to mutate further. In my own case, at the time of my SRT, I had an enlarged lymph node near the prostate bed, which was directly targeted as part of my SRT treatment. So far, so good. The SRT, even with its admitted risks, has worked for me so far. Given that I had PCa in seminal vesicle on one side and at least one lymph node, there is ample reason to believe it may have escaped to further regions of my body. But so far, my PSA says otherwise. Even if it returns, which the nomograms say it well may, I'm convinced that if I hadn't done the SRT 4 years ago when my PSA hit 0.4 and was doubling in under 6 months, I'd have long since been on Luperon, with all of its side effects. But for more than 4 years the SRT has prevented me from having to go there.
-DX March 2002 - PSA 9.4, 5 of 10 cores positive - 30-50%.
-RP April 2002. PT3B N0 MX Gleason=7 (3+4), 75% left lobe; small focus right lobe.
-Post-surgery PSA low of 0.01; slow rise to 0.4 (August 2009).
-SRT Jan/Feb 2010. Enlarged lymph node near prostate bed targeted. Casodex 3 months during SRT
-PSA 0.00 Apr 2013; <0.02 Sep 2013 (new lab); Apr 2014 0.00
Post Edited (Bohemond) : 9/2/2014 11:44:40 PM (GMT-6)