Yup, both up and down.
Put your feet in the shoes of those men whose pathology went down, and no Cancer found after surgery.
Wish I could, actually. Sadly, those shoes don't fit. I know that, for them regret is a huge problem, which I don't envy. But, on the other hand, with Kegels, and PDE5i drugs, and slings, and trimix, and artificial sphincters, and penile implants, they are pretty much guaranteed ways for them to get back to their lives -- to an acceptable new normal -- without the constant worry that the guys face whose post-op Gleason score zigged instead of zagged.
Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012:
3)positive 1 of 14 GS6(3+3) 3-4%, 2nd opinion GS7(3+4)
Mild Pre-op ED
DaVinci RRP 6/14/12. left nerve spared
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12
Incontinent, Trimix, VED, (sling?)Forum Moderator - Not a Medical Professional