Ok, just a couple of things to add here.
You guys already know that I am an exercise fanatic, black belt in Taekwondo, 7 miles a day runner, weight training etc. Also eat very healthy balanced diet.
"Androgen deprivation therapy" is called that because it is the intention
of the chemotherapy intervention to deprive the PCa of testosterone. How ADT chemo actually works is the constant deluge of leuprolide chemical in your blood stream shuts down your pituitary gland completely
. While that indeed stops the production of gonadotrophin
which is supposed to tell your testes to produce testosterone, thus shutting them down, it also
stops production of other hormones.
One of those is Human Growth Hormone, HGH
. HGH is what tells the muscle stem cells in a muscle to reproduce and make more muscle cells to build or repair that muscle. Without HGH it doesn't happen. Also
, HGH tells your hippocampus to produce neural stem cells to replace dead, dying or damaged neurons. Thus the 'mild cognitive impairment' that comes along with ADT chemo.
The loss of "follicle stimulating hormone" FSH
is why your body hair falls out. The loss of "thyroid stimulating hormone" TSH
, causes a drop in your metabolic rate. The now excess calories contribute to your new - found ability to turn excess kcals into fat.
Meanwhile, the lack of prolactin
makes your kidneys retain more water in your blood (water weight gain) and messes with the amount and consistency of the mucus lining in your lungs.
Just as we refer to chemotherapy with Leuprolide chemicals and their analogues as "androgen deprivation therapy" to make it easier to
understand and explain, we blame a bunch of Leuprolide chemotherapy side effects on a simple loss of 1 hormone - testosterone - because that is easy.
The thing is, to deal with the side effects of concern, it will take more than testosterone to address. It takes a suite of hormones to deal with a suite of problem side effects. Through it all, it is of great benefit to each and every one of us to get and stay as active as we possibly can.
66 yo, 2012 PSA=11, biopsy 11/12, 12/12 cores +. DVRP 12/27/12. 36 g gland 35% PCa,EC ext.,1 SV inv,+ marg T3cN0M0, G7(4+3). 2 week post-RP PSA=0.2, start Firmagon ADT. Cont @ 3 mo, EBRT prostate bed and interior pelvic lymph nodes ~ 80 Gy/40 ses. Last 6 mo. Eligard 10/14. 4/15 T=2.2, PSA<.02. 7/16T=184, PSA=.03. 10/16 T=204, PSA=.08, 2/17 PSA=.13, 4/17 T=307 PSA=.19