You are asking a great question. The answer is: not a darn thing. It's just another unnecessary test that raises medical costs for all of us. He's going on a fishing expedition to cover his ***.
What you can do is this instead:
1) Take a PHI blood test. It's inexpensive, and covered by insurance, but is only available from urologists who sign up to give it. Call the number in the attached link to find out how to get it. It's better than PSA and % free PSA and includes both
.Prostate Health Index (PHI)
2) PCA3 is a urine test after a prostate massage. It is more expensive than PHI but is complementary to it. It is covered by insurance after
you've had a negative biopsy, yet suspicion remains. Ask your Uro for it and get pre-cleared by your insurance company.
There are several other biochemical and genetic tests but they are all much more expensive and none are covered by insurance.
So if both of these tests are negative, look for other causes of increased PSA like BPH, prostatitis and blockage.
If these tests are positive, ask for a "multiparametric MRI-targeted biopsy" next time. It's available at many tertiary care centers now - just be careful that the radiologist is experienced - it makes a big difference.
One question- exactly how large is your prostate? PSA goes up in direct proportion to prostate size - normal is .15 ng/ml of PSA per gram (or ml) of prostate. If it's higher than that there may be other contributing factors. If it's that or lower, consider taking Proscar or Avodart to shrink your prostate (and help you pee better). It improves PSA diagnostics too - if PSA fails to go down while taking it or continues to rise - something other than BPH is going on.