Oh, and to add, the Xtandi patient info sheet itself mentions that if side effects become unbearable, one could stop the drug for a few days and retry, or cut the dose in half (2 pills, rather than 4) to let the side effects subside (especially if they are found to be connected to cardiovascular events).
But, of course, it's best to consult with the medical team. It'll be worth it to mention the possibility of reducing the dosage for a bit and see if it improves the situation. THis is assuming the problem is connected to xtandi.
Recently, there was an article about
a study evaluating reduced doses of Zytiga, people are studying whether such steps could help a specific set of patients: prostatecancerinfolink.net/2015/07/06/lower-dosing-of-abiraterone-acetate-in-treatment-of-elderly-prostrate-cancer-patients/