I have been seeing lately a few posters here in a situation with rising PSA, no evidence of metastatc disease, but already castrate-resistant. There is a trial, that I know about
, that is recruiting all over the world exactly such patients: a new generation androgen receptor inhibitor (sort of like Casodex on steroids), potentially a competitor for Xtandi: clinicaltrials.gov/ct2/show/study/NCT02200614
There are some exciting new immunotherapies and vaccine trials for PC that are also recruiting, always good to keep an eye on the clinical trials website. At times the inclusion criteria are very specific (like above) but the obvious advantage is access to new generation medication for free. It is also very important to read the conditions of the trial and discuss with your oncologist (plan A, B, C, what if, what when....).
Father diagnosed in Jan2011 (at age 68):
DRE positive, PSA 7.5, biopsy Gleason 7 and 8.
Bone scan positive: VL5 and pubic bone
Feb2011: Started hormonal therapy (Trelstar+Casodex)
Feb2012: last Trelstar injection
trimonthly PSA: 0.078, 0.138, 1.08, 1.15, 4.17, 5.71, 4.40, 5.08, 7.08
after 2yrs in the OFF phase and a new spot on sacrum, restarts HT May2014
trimonthly: 0.493, 0.207