Don, there is also another alternative to Lupron. If it looks like you may have to stay on it then orchiectomy can remove the lupin from the equation. I know it's a tough call but the guys I know that did it have no regrets. They too were in a situation that looked like a lupron vacation wasn't in the cards. Interestingly, one of the guys I know decided to supplement testosterone after the orchiectomy. He has done well enough. He has other health issues. His PSA has risen but not to the point of discontinuing the T replacement therapy. But he's proven that he can achieve castration levels without Lupron and still have a choice.
Please note: While I work daily with the medical research teams on PCa, I am not a medical doctor. Please talk to your doctor before making decisions.