New Keytruda clinical trial announced - a potentially great new immunotherapy

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Lucy6194
New Member


Date Joined Sep 2017
Total Posts : 1
   Posted 9/23/2017 2:49 PM (GMT -7)   
Husband started clinical trial at Dana farber in Aug. Keytruda every3 weeks and radium 223 every 4 weeks. Go Oct 2 for scans to see how it's working. Diagnosed May 2003. So many drugs trials and chemo to count. All in all doing ok

cspivak
Regular Member


Date Joined Aug 2014
Total Posts : 200
   Posted 9/23/2017 8:31 PM (GMT -7)   
Best wishes for a good response like my husband has had! Do you know whether your husband's cancer has the genetic signature that would have gotten him Keytruda outside the clinical trial (like mine?)

Anyway, keep us posted!
-- Carolyn
Dx 8/14, age 58, PSA 29, G9 (4+5), 11/12 cores, 3 bone mets
Lupron started 9/14, Xgeva 10/14, stop Xgeva 12/14
10/14 PSA 2.0, 12/14 1.1, 6/15 6.87, 6/15 Provenge,9/15 0.8
9/15 osteonecrosis, 6 wk iv antibiotics
1/16 PSA 4.8, 3/16 2, 2/16 spot RT hip
10/16 on Xtandi, 12/16 IMRT
5/17 PSA 8.6, 6/17 PSA 13, 6/17 lymph node biopsy MSI-H, off Xtandi
6/17 Keytruda(pembrolizumab), 7/17 PSA undetectable

Post Edited (cspivak) : 9/23/2017 9:37:59 PM (GMT-6)


jannnett
Regular Member


Date Joined Jan 2015
Total Posts : 116
   Posted 9/23/2017 10:33 PM (GMT -7)   
what genetic signature . can u plz explain?

cspivak
Regular Member


Date Joined Aug 2014
Total Posts : 200
   Posted 9/24/2017 7:47 AM (GMT -7)   
Here's a link to the FDA approval notice. My husband had MSI-H in a lymph node biopsy - that basically means the DNA is really messed up (also referred to as hypermutated). The dMMR the article references are 4 DNA mismatch repair genes MLH1, MSH2, MSH6, PMS2. It's worth emphasizing that the genetic testing can't be done from a blood test (yet, I think, there may be circulating DNA tests that can do that eventually), but from a tissue biopsy.

/www.fda.gov/newsevents/newsroom/pressannouncements/ucm560167.htm

Hope that helps!

-- Carolyn
Dx 8/14, age 58, PSA 29, G9 (4+5), 11/12 cores, 3 bone mets
Lupron 9/14, Xgeva 10/14-12/14
10/14 PSA 2.0, 12/14 1.1, 6/15 6.87, 6/15 Provenge,9/15 0.8
9/15 osteonecrosis, 6 wk iv antibiotics
1/16 PSA 4.8, 3/16 2, 10/16-6/17 Xtandi, 12/16 IMRT
5/17 PSA 8.6, 6/17 PSA 13, 6/17 lymph node biopsy MSI-H
6/17 Keytruda(pembrolizumab), 7/17 PSA undetectable, 9/17 lymph nodes almost resolved

jannnett
Regular Member


Date Joined Jan 2015
Total Posts : 116
   Posted 9/24/2017 9:47 AM (GMT -7)   
Thanks for the link. I read the article, but its not feasible in every setting to perform genetic test first to start Keytruda. I am glad that it helped in your case. However, i had heard several trials are ongoing with keytruda in prostate cancer patients, i am waiting for the results so that i can plan it for my father.


There is always hope turn

Jannet

Tall Allen
Veteran Member


Date Joined Jul 2012
Total Posts : 8787
   Posted 11/9/2017 8:54 PM (GMT -7)   
This clinical trial is very similar to the original post, except it uses Opdivo, which is Bristol-Myers Squibb version of Keytruda, and a different PARP inhibitor, Rucaparib. It starts recruiting the end of November at 36 locations:

/clinicaltrials.gov/ct2/show/study/NCT03338790

The competition between big pharma benefits us.
Allen - not an MD
•PSA=7.3, prostate volume=55cc, 8/17 cores G6 5-35% involvement
SBRT 9 yr onc. resultsSBRT 7 yr QOL results
•treated 10/2010 at age 57 at UCLA,PSA now: 0.1,no lasting urinary, rectal or sexual SEs
my PC blog
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