cabazitaxel which has great impact on destroying wbc in my understanding would kill those T cells and any antibodies created since it has no selective mechanisam
No, it's not like that. It's true that cabazitaxel does cause some
myelosuppression. That means it reduces
the amount of white blood cells (and red ones and platelets) produced by the bone marrow. But it is not
complete suppression. If it were, everyone taking it would die or get seriously ill. Conversely, immunotherapy increases the output of certain kinds or white blood cells like killer T cells and dendritic cells. So immunotherapy, to some extent, corrects for the deficit that chemo causes. In fact, when people get a dangerous symptom called "febrile neutr
openia" from chemo, they are given an immune stimulant called Leukine that is similar to one of the ingredients in many immunotherapies.
Early trials of DCVAC + chemo (in Czechia) looked very good.