The transition zone is what usually enlarges when one has BPH (which, you obviously have). Hopefully, the biopsy will confirm that.
For the BPH, if you're not taking Proscar or Avodart for it already, you may want to discuss that with your doctor. It may have several benefits for you:
• it reduces the size of your prostate, improving your peeing.
• it reduces your PSA -- but only the PSA that comes from BPH,and not the PSA that comes from prostate cancer. That makes PSA a much more sensitive marker for prostate cancer (some people double it, but I don't see the value in that). It establishes a new, lower baseline PSA. Then any consistent increase is suspicious for PC.
• it may prevent new prostate cancer from forming.
• PC became undetectable in half the men on AS who take it.
The downside is it can have sexual SEs.
Also, consider switching to PHI instead of PSA. It includes PSA and a bunch of other indicators that renders it less sensitive to BPH.
Allen - not an MD
•PSA=7.3, prostate volume=55cc, 8/17 cores G6 5-35% involvement
•SBRT 9 yr onc. results
•SBRT 7 yr QOL results
•treated 10/2010 at age 57 at UCLA,PSA now: 0.1,no lasting urinary, rectal or sexual SEsmy PC blog