Update 8/29/18- Dan had his latest PSA test last week. Seems the Zytiga is doing its job. PSA went down to 1.0 and all his other labs were good. Very pleased. BTW ... he is not having any adverse reactions to the Zytiga and prednisone. I do contribute that to y'all .... I learned from y'all to give the Zytiga at exactly the same time every day (7 am) and make sure he drinks lots of water with it ... at 8:30 I wake him up and he takes the prednisone and eats a banana. I also make sure he has at least one glass of Pedialyte sometime during the day. Thanks for all your suggestions, seems to be working well.