Posted 8/6/2017 9:39 AM (GMT -6)
My husband, aka JohnKeats, passed away in April from metastatic prostate cancer. He was only 52. He survived 6 years beyond a stage 4 diagnosis, when he was given only 18 months. This was due in large part to an experimental parp inhibitor which worked to correct the BrCa gene mutation. He lead a relatively normal live, as normal as can be while lupron for 6 years.
In December he started feeling ill with flu like symptoms. We learned then that his cancer developed into such an aggressive form that it did not respond to any treatment and quickly spread to his bone marrow, which ended his life very quickly. His oncologist admitted that long term patients on parp inhibitors are sometimes having the result of experiencing a "super" cancer that no longer responds to treatment.
We traveled to England in October, and he was feeling great, so this came on very quickly, and he was gone six months later. As his wife and life partner, I don't think we would have done anything differently, the parp inhibitor (though clinical trial) gave him six years that he would not have otherwise had, and being a pill form he had little side effects. However it would have been helpful to know that this super cancer was being observed in others taking the drug, so we could have been more vigilant. Perhaps it would have bought him more time, perhaps not.
Just wanted to share this information for those in the same situation. I also wanted to post about his passing. Blessings to you all,