This was mentioned by Doctor WHO above:
"They found that using a mixture of Lupron and Zytiga offered better long term survival than just being on Lupron. An article on this is listed below."
The caution that PDA and garyi are expressing applies even sometimes on this site. Nothing you hear here is a substitute for a discussion with an expert doctor - we are all just raising issues to explore. Doctors expect that these days.
With very few exceptions, HW attracts a great group of people trying to be helpful. In their enthusiasm, some may suggest things that aren't relevant to your specific situation. One of the more difficult lessons that I'm still learning is that prostate cancer is a very diverse group of diseases. Every man's case is slightly different. We have learned recently that even within a single man, there are many strains of his cancer. That genetic diversity increases as the cancer progresses. They call that "genetic breakdown." Once prostate cancer has reached a metastatic stage, it is a wholly different kind of disease from the kind of disease you have, which is called "high risk." Medicines and therapies that are useful in one setting, may not be at all useful, indeed, they may be only toxic, in another setting. What Dr WHO was referring to doesn't apply to you, as far as we know now - it was about
a second-line hormone called Zytiga. They just found out that it increases survival in men newly diagnosed with metastases. Thankfully, you're not at that point. There is currently no evidence that it increases survival in the high risk setting. You couldn't get it anyway, unless you're very wealthy - it's quite expensive and insurance won't cover it for you. I think coping with Lupron is challenging enough, without adding Zytiga to it. But if Lupron doesn't get a great response, your doctor may want to try alternative hormonals. You have to take it one step at a time.
Allen - not an MD
•PSA=7.3, prostate volume=55cc, 8/17 cores G6 5-35% involvement
•SBRT 9 yr onc. results
•SBRT 7 yr QOL results
•treated 10/2010 at age 57 at UCLA,PSA now: 0.1,no lasting urinary, rectal or sexual SEsmy PC blog