This study looks relevant for the discussion in this thread.
It challenge the dogma of using SRT at the very first sign of recurrence in all
patients regardless of disease characteristics. Instead, it showed a clear benefit of early SRT only in certain subgroups of men with either BCR or PSA persistence after surgery.Impact of Early Salvage Radiation Therapy in Patients with Persistently Elevated or Rising Prostate-specific Antigen After Radical Prostatectomy
Five distinct risk groups were identified based on clinical and pathologic characteristics. Early SRT administration was noted to be associated with improved cancer control for low-, intermediate-, and high-risk patients. Conversely, very low-risk (undetectable PSA after RP, Gleason score ≤ 7, and tumour stage ≤ pT3a) and very high-risk patients (PSA persistence after RP, and Gleason score ≥ 8) did not benefit from early salvage treatment.
Pratoman, you (like me) might find this statement reassuring (unfortunately not applicable for az and gari):Particularly, very low-risk patients (undetectable PSA after RP, Gleason score ≤ 7, and tumour stage ≤ pT3a) had a quite favourable 8-yr metastasis-free survival of 98%, and these patients’ outcomes were not influenced by pre-SRT PSA level.
Age at detection: 60
PSA 4.1 2014-02-25
Biopsy 2014-04-24, 4 of 10 cores positive, G: 3+4,4+3,4+3 EPE,4+3. PNI+
Bone scan negative
DaVinci 2014-08-31, nerve sparing right side
Prostate 35 g, 46x37x38 mm
Tumor dorsal PZ, SV-, 14 LN-, SM-, pT3a, G7 (4+3), EPE+ left side