BillyBob - here is another study about rye. Rye bread consumption during adolescence was associated with a decreased risk of prostate cancer. But they found that mid- or late life consumption was not associated with prostate cancer. Other studies have also suggested that high milk intake in early life, but not in midlife, is a risk factor. This seems to be in line with that asian immigrants entering western countries in their twenties retain prostate cancer incidence rates similar to those in their native country. Could there be anything in this?
Then it is too late for us and our sons but perhaps not for our grand sons?
Rye Bread Consumption in Early Life and Reduced Risk of Advanced Prostate Cancer
So unfortunately it looks like the usual conflicting studies that can prove so frustrating. But maybe this study(linked in my OP ) still give us a bit of hope for things we can do later in life, as it was an intervention study, though I doubt it qualifies as double blind, too small etc so it is not maximum quality. Most likely the men knew whether or not they were in the high Rye group, or not. So there could be some placebo effect. Still, if so, the placebo managed to lower PSA 14% and way more impressively kill off 180% more PC cells than the white bread over 3 weeks, so who knows, maybe it is of some use. ( how did they get these men to agree to another biopsy in just 3 weeks?
) Plus, we have had some other studies of men with PC under AS given ground flax seed with promising results. All of these, of course, would count as a latter life intervention as opposed to what happens in youth. I can hope there is a benefit, at least. I don't mind adding some flax seed to my breakfast. I don't get that much gas from it, but my wife had to abandon it! ( both Rye and Flax seed = lignans, but flax seed is way more with out having to eat a pound of bread per day)/www.ncbi.nlm.nih.gov/pubmed/15134976
Dietary factors may influence the prostate and have an impact on prostatic growth and disease. A small number of studies have suggested that flaxseed-supplemented, fat-restricted diets may thwart prostate cancer growth in both animals and humans. Unknown, however, is the potential effect of such a diet on benign prostatic epithelium.
We undertook a pilot study to explore whether a flaxseed-supplemented, fat-restricted diet affects the proliferation rates in benign epithelium. We also explored the effects on circulating levels of prostate-specific antigen (PSA), total testosterone, and cholesterol. Fifteen men who were scheduled to undergo repeat prostate biopsy were instructed to follow a low-fat (less than 20% kcal), flaxseed-supplemented (30 g/day) diet and were provided with a supply of flaxseed to last throughout the 6-month intervention period. The PSA, total testosterone, and cholesterol levels were determined at baseline and at 6 months of follow-up. Reports from the original and repeat biopsies were compared, and proliferation (MIB-1) rates were quantified in the benign prostatic epithelium.
Statistically significant decreases in PSA (8.47 +/- 3.82 to 5.72 +/- 3.16 ng/mL; P = 0.0002) and cholesterol (241.1 +/- 30.8 to 213.3 +/- 51.2 mg/dL; P = 0.012) were observed. No statistically significant change was seen in total testosterone (434.5 +/- 143.6 to 428.3 +/- 92.5 ng/dL). Although 6-month repeat biopsies were not performed in 2 cases because of PSA normalization, of the 13 men who underwent repeat biopsy, the proliferation rates in the benign epithelium decreased significantly from 0.022 +/- 0.027 at baseline to 0.007 +/- 0.014 at 6 months of follow-up (P = 0.0168).
These pilot data suggest that a flaxseed-supplemented, fat-restricted diet may affect the biology of the prostate and associated biomarkers. A randomized controlled trial is needed to determine whether flaxseed supplementation, a low-fat diet, or a combination of the two regimens may be of use in controlling overall prostatic growth.
Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3577-87. doi: 10.1158/1055-9965.EPI-08-0008.
Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.
Demark-Wahnefried W1, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT.
Division of Cancer Prevention and Population Sciences, The University of Texas M. D. Anderson Cancer Center, P.O. Box 301439, Unit 1330, Houston, TX 77230-1439, USA. firstname.lastname@example.org
Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies.
We undertook a multisite, randomized controlled trial to test the effects of low-fat and/or flaxseed-supplemented diets on the biology of the prostate and other biomarkers. Prostate cancer patients (n = 161) scheduled at least 21 days before prostatectomy were randomly assigned to one of the following arms: (a) control (usual diet), (b) flaxseed-supplemented diet (30 g/d), (c) low-fat diet (<20% total energy), or (d) flaxseed-supplemented, low-fat diet. Blood was drawn at baseline and before surgery and analyzed for prostate-specific antigen, sex hormone-binding globulin, testosterone, insulin-like growth factor-I and binding protein-3, C-reactive protein, and total and low-density lipoprotein cholesterol. Tumors were assessed for proliferation (Ki-67, the primary endpoint) and apoptosis.
Men were on protocol an average of 30 days. Proliferation rates were significantly lower (P < 0.002) among men assigned to the flaxseed arms. Median Ki-67-positive cells/total nuclei ratios (x100) were 1.66 (flaxseed-supplemented diet) and 1.50 (flaxseed-supplemented, low-fat diet) versus 3.23 (control) and 2.56 (low-fat diet). No differences were observed between arms with regard to side effects, apoptosis, and most serologic endpoints; however, men on low-fat diets experienced significant decreases in serum cholesterol (P = 0.048).
Findings suggest that flaxseed is safe and associated with biological alterations that may be protective for prostate cancer. Data also further support low-fat diets to manage serum cholesterol.
Post Edited (BillyBob@388) : 9/28/2017 5:39:36 PM (GMT-6)