What is HGPIN in Prostate Biopsy mean?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Oct 2017
Total Posts : 81
   Posted 11/8/2017 9:01 AM (GMT -6)   
My husband diagnosed with prostate cancer.
One core shows HGPIN, what's it's mean?

Regular Member

Date Joined Oct 2017
Total Posts : 54
   Posted 11/8/2017 9:10 AM (GMT -6)   
High-grade prostatic intraepithelial neoplasia is considered the most likely precursor of prostatic carcinoma. The only method of detection is biopsy; prostatic intraepithelial neoplasia (PIN) does not significantly elevate serum prostate-specific antigen concentration and cannot be detected by ultra-sonography. The incidence of PIN in prostate biopsies averages 9% (range, 4%–16%), representing 115,000 new cases of PIN diagnosed each year in United States. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeated biopsy for concurrent or subsequent invasive carcinoma. Carcinoma will develop in most patients with PIN within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype that are intermediate between normal prostatic epithelium and cancer, indicating impairment of cell differentiation and regulatory control with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention.

Veteran Member

Date Joined Jan 2012
Total Posts : 8797
   Posted 11/8/2017 10:07 AM (GMT -6)   
He's got PC, you can ignore HGPIN, treat the PC.
I'll be in the shop.
Age 57, 52 at DX
4.2 10/11, 1.9 6/12, 1.2 12/12, 1.0 5/13, .6 11/13,
.7 5/14, .5 10/14, .5 4/15, .3 10/15, .3 4/16, .4 10/16, .4 5/17, .3 10/17
G 3+4
Stage T1C
2 out of 14 cores positive
Treatment IGRT - 2/2012
My latest blog post

Veteran Member

Date Joined Apr 2017
Total Posts : 754
   Posted 11/8/2017 11:13 AM (GMT -6)   
Shop is right.

High Grade PIN only means that he is likely to have prostate cancer, which you already know.

It sounds scary, but it is nothing to be alarmed about.
2014-15: PSA's 9, 12, 20, 25... Neg DRE, Neg TRUS biopsy
6/16: MRI Fusion biopsy, Right Base, 2x40%+2x100% all G8 (4+4)
8/16: DaVinci RP, 6mm EPE, PNI, 25% G4, BL SVI, stage T3B N0M0
1/17: started 18 months Lupron ADT, PSA's ~.03
5/17: AMS800 AUS implanted, revised 5/30
39 tx RapidArc IMRT (70 Gy) Aug-Oct 2017
Remember, remember... MOVEMBER!

Regular Member

Date Joined Aug 2017
Total Posts : 244
   Posted 11/10/2017 7:50 AM (GMT -6)   
Had HGPIN on my biopsy also — Philmire explained it well, and if he moves forward with treatment the PIN won’t have time to advance.
Age 75, excellent health except PCa
7/20/17, Biopsy, 5/12 cores PCa all right side, none on left, Gleason 4+3, PNI, suspicion of EPE
PSA 20.44
MRI and CT no evidence of metastasis, no lymph nodes, no seminal vesicles, focal bulge
Laparoscopic surgery 10/31/17, left nerves spared
11/9/17 catheter out, little leakage, pathology report T3aN0, G4+3, focal EPE, no cancer at any surgical margins
New Topic Post Reply Printable Version
Forum Information
Currently it is Thursday, July 19, 2018 11:16 PM (GMT -6)
There are a total of 2,983,473 posts in 327,124 threads.
View Active Threads

Who's Online
This forum has 161915 registered members. Please welcome our newest member, Manystripes.
353 Guest(s), 10 Registered Member(s) are currently online.  Details
ezhoe, wibblypig, DonN, PDL17, island time, Scaredy Cat, Girlie, rancherdave, Fletch10, Redwhite&blue