What is HGPIN in Prostate Biopsy mean?

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Regular Member

Date Joined Oct 2017
Total Posts : 46
   Posted 11/8/2017 7:01 AM (GMT -7)   
My husband diagnosed with prostate cancer.
One core shows HGPIN, what's it's mean?

Regular Member

Date Joined Oct 2017
Total Posts : 53
   Posted 11/8/2017 7:10 AM (GMT -7)   
High-grade prostatic intraepithelial neoplasia is considered the most likely precursor of prostatic carcinoma. The only method of detection is biopsy; prostatic intraepithelial neoplasia (PIN) does not significantly elevate serum prostate-specific antigen concentration and cannot be detected by ultra-sonography. The incidence of PIN in prostate biopsies averages 9% (range, 4%–16%), representing 115,000 new cases of PIN diagnosed each year in United States. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeated biopsy for concurrent or subsequent invasive carcinoma. Carcinoma will develop in most patients with PIN within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype that are intermediate between normal prostatic epithelium and cancer, indicating impairment of cell differentiation and regulatory control with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention.

Veteran Member

Date Joined Jan 2012
Total Posts : 7901
   Posted 11/8/2017 8:07 AM (GMT -7)   
He's got PC, you can ignore HGPIN, treat the PC.
I'll be in the shop.
Age 57, 52 at DX
4.2 10/11, 1.9 6/12, 1.2 12/12, 1.0 5/13, .6 11/13,
.7 5/14, .5 10/14, .5 4/15, .3 10/15, .3 4/16, .4 10/16, .4 5/17, .3 10/17
G 3+4
Stage T1C
2 out of 14 cores positive
Treatment IGRT - 2/2012
My latest blog post

Regular Member

Date Joined Apr 2017
Total Posts : 386
   Posted 11/8/2017 9:13 AM (GMT -7)   
Shop is right.

High Grade PIN only means that he is likely to have prostate cancer, which you already know.

It sounds scary, but it is nothing to be alarmed about.
2014-15: PSA's 9, 12, 20, 25... Neg DRE, Neg TRUS biopsy
6/16: MRI Fusion biopsy, Right Base, 2x40%+2x100% all G8 (4+4)
8/16: DaVinci RP, 6mm EPE, PNI, 25% G4, BL SVI, stage T3B N0M0
1/17: started 18 months Lupron ADT, PSA's ~.03
5/17: AMS800 AUS implanted, revised 5/30
39 tx RapidArc IMRT (70 Gy) Aug-Oct 2017
Remember, remember... MOVEMBER!

Regular Member

Date Joined Aug 2017
Total Posts : 37
   Posted 11/10/2017 5:50 AM (GMT -7)   
Had HGPIN on my biopsy also — Philmire explained it well, and if he moves forward with treatment the PIN won’t have time to advance.
Age 75, excellent health except PCa
7/20/17, Biopsy, 5/12 cores PCa all right side, none on left, Gleason 4+3, PNI, suspicion of EPE
PSA 20.44
MRI and CT no evidence of metastasis, no lymph nodes, no seminal vesicles, focal bulge
Laparoscopic surgery 10/31/17, left nerves spared
11/9/17 catheter out, little leakage, pathology report T3aN0, G4+3, focal EPE, no cancer at any surgical margins
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