Changing Standard of care for metasticized prostate cancer

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NickAlive
New Member


Date Joined Nov 2017
Total Posts : 1
   Posted 11/11/2017 11:01 AM (GMT -7)   
of this summer, both the Standard of Care for newly discovered metasticized prostate cancer has changed, and an alternate variant has also been discovered. The use of chemotherapy with docetaxel in addition to Lupron as soon as it is discovered, on a USA test gave a mean survival of 6 years 9 months, though a test in Britain gave a shorter survival time.

But also Zytiga with Lupron seemed to show a similar benefit, of about 1 1/2 years beyond that without starting simultaneous therapy. That however is not yet Standard of Care.

My understanding is that many urologists have not yet caught up with the changed benefit.

Everton
Regular Member


Date Joined Jun 2017
Total Posts : 33
   Posted 11/11/2017 12:19 PM (GMT -7)   
NickAlive

I was diagnosed late 2016. I was given Lupron by my Urologist pretty much immediately. Within a short period of time I was given Docetaxel by my Medical oncologist. I also got radiation to one of my hips. This was all done by late 2016 early January 2017.

Edit: After chemo my lungs are clear as while as my hip.

Recent psa test show 0.018
Age 59 when DX
DX Nov 2016
PSA 350
Start Lupron every 3 months
Jan 4 PSA 10.3
Feb 4 PSA 0.60
Feb Testosterone 0.2
Nov scan shows Bone & Lung Mets
Dec radiation to hip
Jan Biopsy 12 samples all positive
Gleason 9 ( 5 + 4 )
Jan Start chemo 6 times 3 weeks apart, Apr 21 done
Docetaxel with Predisone
March start Zometa
April 4 Turp due to prostate collapsing around urethra

Post Edited (Everton) : 11/11/2017 1:41:44 PM (GMT-7)


Notam
Regular Member


Date Joined Jul 2017
Total Posts : 48
   Posted 11/11/2017 12:36 PM (GMT -7)   
May I presume this refers to distant metastasis and not locally advanced PCa? Thnx
59@dx - no family PCa history
01/17 - 5.65 PSA, DRE+ Rt Base node at routine physical
04/17 - 6.67 PSA, cT2a at Uro consult
06/17 - TRUS-Bx 6/14 cores+, all G(3+4)=7; 10%x2,60%,70%,90%x2; PNI+Cribriform Morphology
08/17 - CT, Bone Scan Neg
09/17 - 3TmpMRI EPE w/ Rt NVB invasion PIRADS-5 cT3aN0M0 Stage III
09/17 - 2nd opinion on Bx slides: same +focal mucinous features
Start Casodex/Eligard
SBRT

Cyclone-ISU
Veteran Member


Date Joined Oct 2014
Total Posts : 971
   Posted 11/11/2017 12:48 PM (GMT -7)   

Hello NickAlive ~

Welcome to this forum! We welcome you here!

Your post brings up an important topic --- the breakthrough medications and treatments that have emerged in the past few years ---

I am starting my fifth year of treatment and survivorship, following a diagnosis of advanced prostate cancer when I was in my 40s ...

I stand in humble gratitude to the scientists and researchers who continue to push forward on new breakthroughs ... and fellow comrades who have gone before me, volunteering to participate in clinical trials, all in the interest of helping others in the future.

As well, your post also brings up another aspect --- finding new ways to sequence EXISTING treatments, in new ways --- or in combination with other medications and treatments.

I was in the first wave of fellows here who "jumped on board" when the new recommendation for the "early chemo plan" was first endorsed and recommended ...

Starting chemo, I didn't quite know what to expect ... but with each subsequent infusion, my PSA crept downward ... that was over three years ago now, and I truly believe it helped me. I was my doctor's first patient who was treated with the new "early chemo plan" recommendation.

Since then, other friends of mine have also pursued the "early chemo plan" ... along with MANY of my brothers here on this forum ... just one example of how research is suggesting new ways to help our fellow comrades who face a cancer diagnosis. We have all supported each other here, through and through ...

From there, I also started taking ZYTIGA, after my chemotherapy infusions were finished up. Again, it was a relatively new medication ... approved by the F.D.A. in recent times ... my oncologist recommended it as a "next step" in helping to suppress my PSA levels ... I have now been on ZYTIGA for 28 continuous months ... it continues to help me ... it is also helping other friends of mine.

Your post refers to new studies that show that ZYTIGA may move "up the line" to become a line of defense medication, in specific cases, upon diagnosis. I hope that other comrades will be helped by these newer medications that have emerged in recent times ... XTANDI, PROVENGE, XOFIGO, ZYTIGA ... and I hope this is just the beginning of the list of F.D.A. approvals that will emerge in the foreseeable future.

You bring up another interesting point ... making sure that all doctors become aware of new treatments or medications ... I have seen MANY examples where this forum has helped "spread the word" and readers here have had informative talks with their doctors ... and sometimes, even bringing them copies of clinical trial results ... all in the interest of helping others. This forum has helped so many readers, over the course of time ...

That's why it continues to be important to keep sharing our treatment experiences ... sharing first-hand stories ... posting new findings on forums like this ... staying connected to our doctors and medical teams ... asking questions ... staying updated on new research ... and continuing to "network" with others who stand alongside us in this health concern.

Research is finding new ways to help us, bit by bit, step by step ... and we all wait for further innovations and breakthroughs ...

Thanks for posting today, NickAlive ... we're pleased to welcome you here as a new, contributing member in this BAND OF BROTHERS ... and SISTERS, too!

Handshake to welcome you, from across the miles,
"Cyclone" ~ Iowa State University
PSA At Diagnosis In Year 2013 : 138
Initial Diagnosis: Advanced Prostate Cancer, With Metastases In Both Lungs
Age At Diagnosis: 48 years
ADT Treatments: LUPRON, FIRMAGON, and currently ZOLADEX
Subsequent Treatments: Chemotherapy (TAXOTERE) & now ZYTIGA
Additional Consultant - Dr. KWON - Mayo Clinic
Current PSA Level: < 0.50, Treatments Ongoing

Post Edited (Cyclone-ISU) : 11/11/2017 3:37:18 PM (GMT-7)


Larry E
Regular Member


Date Joined May 2016
Total Posts : 112
   Posted 11/11/2017 3:38 PM (GMT -7)   
Hi NickAlive,
My Medical Oncologist was more aware of the new changes than my Urologist.
We must stay on top of new treatments and clinical trials and the best way I have found is to log in here and read.
Larry E
Dx 2015 62yrs Tulsa G-9 PSA 203 Distant bones mets
5/15 Fermagon initial ADT, Xgeva
7/15 Eligard /6mo Vit D3 7/15 Taxotere
8/16 New bone mets 10/16 Lung nodes
12/16 Provenge
PSA Sep 1.3, July 1.3, June 1.1, May 1.0
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