JK - I've been on Lupron for eleven months now, third six month injection and PSA scheduled for next month. Initial effect was a surge in sexual energy, the "Lupron flare", which subsided in about ten days. I've read that some physicians elect to pre-treat with two weeks of Casodex to prevent the flare, but mine did not.
Hot flashes and the associated night sweats crept up on me over the next few weeks and by six weeks became intolerable. At three months I begged my RO for help but that fell on unsympathetic ears. He told me to hire a personal trainer.
Which leads me to say that most of what I've read in this thread is spot on, with exception of the mention of exercise being a cure all for the SE's of HT. With two of the most common SE's being muscle loss and lack of interest or enthusiasm for just about everything, how is someone who already feels weak and fatigued and uninterested in practically everything supposed to suddenly become a mesomorph? It usually just doesn't work that way. If your husband is already so inclined, then then he has that to his favor.
In addition to the very common hot flashes, I was hit pretty hard by extreme moodiness. This affected me at a time when my life was already an emotional roller coaster. My GP was also unsympathetic. Through my own research I discovered Venlafaxine and shopped for a physician willing to prescribe this fairly innocuous medication. In addition to John's statement above I can attest to the efficacy of Venlafaxine in alleviating the frequency, severity and intensity of both the hot flashes and mood swings caused by HT, I would say by about 50%.
Additional medical issues which rose over the past year found me taking a fairly high dose of Gabapentin daily, which has further reduced the incidence of nighttime flashes and sweats, albeit at the cost of additional daytime drowsiness and lethargy. Why the medical community chooses to keep these treatments a secret is beyond me.
My wife of 37 years is a BSN/RN and was a CRRN at a rehab facility for nearly forty years before our recent retirement. She says that she has had patients on much higher doses than those that I've found to be effective. These are not drugs of abuse, and it is unfortunate that I had to endure months and years of anguish before - through my own advocacy, I was able to prescribe my own cure. Aren't doctors supposed to learn about this in medical school?
2014-15: PSA's 9, 12, 20, 25... Neg DRE, Neg TRUS biopsy
6/16: MRI Fusion biopsy, Right Base, 2x40%+2x100% all G8 (4+4)
8/16: DaVinci RP, 6mm EPE, PNI, 25% G4, BL SVI, stage T3B N0M0
1/17: started 18 months Lupron ADT, PSA's ~.03
5/17: AMS800 AUS implanted, revised 5/30
39 tx RapidArc IMRT (70 Gy) Aug-Oct 2017
Remember, remember... MOVEMBER!