My RO released me from his care in January when my PSA was holding steady between .04 and .05 for 2 years, and told me to get my PSA checked yearly during my annual physical with my GP. I did this in July, and my PSA had jumped 40% from .045 to .063. Coincidentally, I was diagnosed at that time with type 2 diabetes. He prescribed 1000mg of metformin for me twice daily, and told me to get my labs done in November. I did that, and not only did my A1C go down from 6.6 to 6.0. But my PSA went down 19% back to .051. I have also been on 20mg of atorvistatin for years. This held my cholesterol at about 200. This check, my cholesterol dropped to 158, and triglycerides dropped from 333 (gravy) to 97. Not convinced yet that it is a miracle drug, but my numbers would indicate that it had an effect. I have also dropped 30 lbs while on it. I'll take it.
Well, it seems you have lucked out by getting T2 diabetes
, because, as has been pointed out on this forum a few times- sometimes to prove that excess sugar has no relationship to PC- diabetes has been associated with protection from PC. So there you go, get 1 disease, avoid the other.
I have been the steady spoil sport regarding that lucky(?) swap of diseases, however, by pointing out that quite possibly it is not the diabetes and it's attendant high blood sugars and blood insulin that is protecting against the PC, but rather the treatment
of the diabetes, which has a goal of lowering both blood sugar and insulin. And sense virtually all folks diagnosed with T2D or even pre-diabetes get some sort of treatment for it, even if nothing more than a sugar lowering diet, or oral drugs that increase insulin sensitivity(thus lowering blood insulin) such as Metformin, it should not be surprising that they also appear to get some "protection" from PC. And it appears that Metformin has improved your sugars and insulin, just judging by your A1C.
Now, is that the reason for your drop of PSA? Hard to tell for sure, folks do see these random fluctuations. Up and then back down, sometimes being clueless as to the cause. Then again, Metformin has been touted by some as possibly beneficial in the war against PC- even for non-diabetics I think. So though it may be just a random coincidence that your PSA dropped for unknown reasons at exactly the same time as you improved your blood sugar and A1C #s by taking Metformin(any diet changes?), it seems at least equally likely that your #s improved because
you improved sugar/insulin with the drug and dietary improvement, if any.
Since more carbs/sugar in the diet have been shown repeatedly to be associated with- among many other nasties- higher triglycerides, and improvements of the order which you have seen are easily accomplished by cutting net carbs/sugar(I have been known to go from over 200 to 49 in < 6 months, no drugs, and have never exceeded 80 during the 18 years since, just because I always at least make some tiny effort to take it easy on the sugar, occasionally very careful about
that). Also has been known to help with cholesterol, especially raising HDL. How was your HDL?
Since cutting net carbs/sugar can have such a profound effect on these blood tests, as well as blood sugar and A1C, ( it is very hard to suffer from T2D- aka sugar diabetes- if you eat little or no sugar/net cabs), then I personally would not be surprised if a drug that has a positive result on blood sugar, A1C and blood insulin levels, would have many of the same effects. Any unwanted SEs from the drug?
Post Edited (BillyBob@388) : 11/28/2017 9:16:23 AM (GMT-7)