Grinnell86, i went on metformin 1700 mg/day and atorvastatin in March 10mg. lipids improved and today the psa dropped from .05 to .04. But isn't the metformin just masking the true PSA? It might make a difference for me as I approach SRT. Should I be waiting 10-13 days (the studies show it remains in plasma for up to 13 days) and retest to find out my "true" value, or just accept this as my fully-dosed metformin/statin adjusted psa and go from here. I don't want to be lulled into not acting with SRT.
Have call into Paul Nguyen at Dana Farber. Thoughts?
Some folks think that Metformin helps with the fight against PC, other cancers and a bunch of other issues. I do not know if this has ever been proved, but I wouldn't be surprised if it does.
However, I'm pretty sure it is proven that Metformin improves insulin sensitivity, thus leading to lower blood insulin levels as well as lower blood sugar levels. Insulin resistance(opposite of sensitivity) and higher blood insulin levels are heavily implicated in poorer outcomes for numerous cancers, including 3 to 8 times worse for PC.
So, it is at least reasonably possible that Metformin is not just masking your PSA, but actually improving your PC status, meaning fewer PSA producing PC cells left alive. It is def possible. Any dietary approach that lowers blood sugar/insulin will probably help as much or more than Metformin.
We were told by some authorities that T2 diabetes was actually protective against PC. Which was the ONLY cancer that diabetes was not actually harmful for. So we were told that PC was different from all other cancers, and what helped with them might make PC worse(even though all responded to surgery, RT and often ADT. But I have long called BS on that, and studies showing that greater blood insulin = worse PC ( and all other cancer) outcome back me up. I always said it was not the T2D that was protective, it was the TREATMENT for T2D, which during the early stages lowered blood insulin( i.e. Metformin and improved diet). And this lowering of blood sugar and insulin often started 10-30 years before PC is normally diagnosed. Hence, less insulin to promote growth of PC cells, over decades when the PC might be growing.
Therefore, I would not be overly concerned about
your Metformin. If anything, be concerned about
the amount of carbohydrates in your diet, which cause you to need Metformin in the first place. Good luck!
Post Edited (BillyBob@388) : 5/1/2019 10:23:10 PM (GMT-6)