Immunotherapy and weird S&!t - literally

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cspivak
Regular Member


Date Joined Aug 2014
Total Posts : 205
   Posted 12/7/2017 2:55 PM (GMT -7)   
This article in Science is too weird not to share:

“Gut microbes shape response to cancer immunotherapy”

Basically, a couple recent human studies with PD-1 blockers are showing that what type of gut bacteria you happen to have can affect whether or not you respond. And taking antibiotics before immunotherapy can reduce response. Trials will be starting in 6-8 months on whether fecal implants (!!) could help more melanoma patients respond to PD-1 blockers.

Not making it up.
Dx 8/14, age 58, PSA 29, G9 (4+5), 11/12 cores, 3 bone mets
Lupron 9/14, Xgeva 10/14-12/14
10/14 PSA 2.0, 12/14 1.1, 6/15 6.87, 6/15 Provenge,9/15 0.8
9/15 osteonecrosis, 6 wk iv antibiotics
1/16 PSA 4.8, 3/16 2, 10/16-6/17 Xtandi, 12/16 IMRT
5/17 PSA 8.6, 6/17 PSA 13, 6/17 lymph node biopsy MSI-H
6/17 Keytruda(pembrolizumab), 7/17 PSA undetectable, 9/17 lymph nodes almost resolved

CuriousCharles
Regular Member


Date Joined May 2017
Total Posts : 186
   Posted 12/8/2017 10:29 PM (GMT -7)   
Carolyn,

Yes, very interesting stuff. I can certainly believe that gut flora can be interconnected with all kinds of things. (I also recall seeing nature films of elephants using their trunks to pull and eat droppings from other elephants. No doubt for some very good reason.) Bacteria rule.

Off Topic: (sort of)

I once read a book that had the imaginative premise that practically all land plants were constructed of little collectives of bags of water - much like sea water - so that the microscopic rootlets of plants could present their moist liquid surfaces to new sources of minerals on the land that were previously inaccessible to life in the oceans. A process involving hundreds of millions of years, and, eventually, great interlocking biological intricacies.

Similarly, mobile, larger, multicellular animal life forms could be conceived of as a way for the myriad of symbiotic bacteria within them to be moved from place to place upon the land or in the waters, while protected in a stable environment, to find and exploit new sources of food and energy.

The primary "actors" were/are the Ocean and the simplest life forms like the Bacteria. Neither have any "brains" to direct them, but given enough time, emergent order arises out of chaos - not so unlike how moving water in streams or air in the sky create well-ordered "ripples" in elegant rows on different physical scales.

Charles
Dx Nov 2013 Metastatic Prostate Cancer at Age 65
Numerous Bone Mets and Lymph Nodes, PSA 5,006
ADT Lupron + Zometa, PSA Nadir 1.0
Resistance after two years.
Short rechallenge Casodex.
Oct 2016 Provenge
Dec 2016 Start Xtandi, PSA 95
Sep 2017 Xtandi PSA Nadir 1.2
Nov 2017 PSA 1.7
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