Interesting read, TA and if I may say so, I might well be the poster child for adjuvant HT and ART administered based solely upon adverse pathology, before any significant post-op PSA increase. Many of the stats in this study fit my case to a "T"... G8, SVI, -LNI. Based upon my first post-RT uPSA being 0.00 it looks like everything worked in my favor despite seemingly having everything going against me going in.
But one item in the nomogram puzzles me /pcnrv.blogspot.com/2016/08/probability-of-remaining-recurrence.html
... I've gone thru the calculation before "as is"
and was wondering why positive surgical margins
appears to be favorable and negative margins unfavorable. Or do I misunderstand something?
In every other facet, more adverse pathology adds points to the score (Gleason, stage, +SVI, -ADT) while more favorable conditions score zero... except SM. Positive SM scores 0 and negative SM scores 27. Wouldn't it logically be the other way around?
Or am I seeing things backwards?
Risk Factor Score (points)
ADT Yes: 0 No: 49
Gleason score 6: 0 7: 54 8: 70 9/10: 90
Extraprostatic Extension No:0 Yes:22Surgical Margins Positive: 0 Negative: 27
Seminal Vesicle Invasion No: 0 Yes: 24
Pre-RT PSA (ng/ml) 0.05: 2.5 0.1: 5 0.2:10 0.3: 15 0.5: 25 1.0: 50 1.5: 75
Radiation dose (Gy) ≥66 Gy: 0 <66 Gy: 17