Would be interesting to know if this applies only to those with metabolic syndrome prior to PCa. It seems that we know that ADT can cause metabolic syndrome ( I seem to be seeing it) so can the treatment of PCa with ADT actually contribute to more aggressiveness?
I never had any concerns with Diabetes prior but I just started on Metformin due to blood glucose levels beginning to rise one year+ now into ADT despite eating mostly vegetables and hitting the gym daily.
With your doctors permission of course, consider intermittent fasting and/or a ketogenic diet, or even just periodically lowering carbohydrate food intake. Either or both of those will probably do a lot more to lower your average blood sugar and probably more importantly, your blood insulin levels, than Metformin. Excess blood insulin, which appears immediately in response to consumption of sugar/carbs, is quite likely a bottom line root cause(or at least one of several causes) of all types of ailments. Intermittent fasting/low carb eating (either/or both) have, in numerous studies, lowered blood insulin by a lot, even more than they lower sugar.
You see, the body produces insulin for the primary purpose of getting sugar(glucose) out of your blood into the cells for energy needs, or out of the blood to be stored as fat. High blood sugars are toxic, so the sugar needs to be moved out. If you lower the amount of carb/sugar put into the system, less insulin is needed to get the sugar out of the blood. So, even if your blood sugar stays about
the same(hopefully down in a normal range), you will likely have way less blood insulin, since not as much is needed to lower blood sugar if you put less sugar in.(conversely, you can have a normal blood sugar but already have a high blood insulin, needed to keep your sugar normal) Over time, with less sugar, your body will become less insulin resistant. That is a main way that Metformin works, by increasing insulin sensitivity/decreasing insulin resistance. High levels of blood insulin and/or insulin resistance are HIGHLY associated with the occurrence, recurrence and advance of all types of cancer, including PC(as well as many other nasties, like metabolic syndrome). And let's not forget weight gain and high triglycerides.
It is pretty easy to lower blood insulin, drugs are not even needed. Just cut way back on foods that raise blood sugar, replace with fat if the calories are needed, and insulin will drop. Or, fast. Fasting is zero carb/sugar during the fast. It is also zero protein, and protein can also raise blood insulin somewhat. It is also zero fat, but fat does not do much at all to raise insulin, as far as I know. But all (NET: carb minus fiber) carb consumption = immediate rise in blood insulin. So it is really not rocket science, and drugs are not really needed for those who will take the dietary approach. I doubt there has been a Type 2 diabetic/insulin resistant/metabolic syndrome person in history who did not eat an abundance of net carbs. Type 1 - the minority- is different- their bodies do not make adequate or any insulin, so they must inject it or die. This is the opposite of type 2 diabetics, who have way too much insulin due to insulin resistance, and who may finally end up also injecting insulin because even though they make a lot, they can not make enough to overcome the sugar input and their insulin resistance. It all ends up a big negative for all manner of health issues, not just cancer. Blindness, amputations, high BP/strokes, heart attacks, etc, etc, etc. All tied in closely with excessive insulin production, which is tightly related to high net carbohydrate intake.
Most vegetables, though 100% carb, are very low net carb, due to high fiber content, so you can eat about
all you can stand of them. Less so for fruits, but some are not too bad. Most breads, pastas, potatoes, many others and of course desserts, are all maxed out net carb, whether low fat or high fat.
Your link did not work for me. I got "access to website blocked"? (never mind, it was my VPN )
Post Edited (BillyBob@388) : 2/4/2018 2:36:03 PM (GMT-7)