When the prostate is removed there is no further PSA expression unless cancer or some prostatic tissue was left behind. With the half life of PSA in the blood stream being about
5 days (as I remember) , the PSA should be undetectable within 90 days if all the prostate and cancer was removed. Undetectable would clearly be a nadir. That is why 90 days is the standard for the first post-surgical PSA test. If PSA is detectable at that point it is indicative the surgery was probably not successful and additional treatment may be needed. It may be the nadir has been reached and PSA will start increasing as we have seen with many men on this board who had unsuccessful surgeries.
Remember the nadir is the low point. Some never reach undetectable PSA as their nadir. Some reach it, but than suffer recurrence as PSA starts rising. So using surgery most men should reach that low point in a few months since the prostate is gone and hopefully all the cancer with it. With radiation, the prostate is intact will often continue to express PSA. We have discussed how the radiation kills the PCa over time and thus there will continue to be PSA expression until this process is complete. That can take years, never months. Just the opposite of surgery.
Again, this poll is for radiation as a primary treatment. It should not include anyone that used surgery. That SRT may also have been used is irrelevant to this poll and will only distort the results and confuse the men who used radiation as their primary treatment.
PSA 59 on 8-26-2010 age 60. Biopsy 9-8-2010 12/12 positive, 20-80% involved, PNI in 3 cores, G 3+3,3+4,and 4+3=G7, T2b.
Eligard and Jalyn started on 10-7-2010. IMRT to prostate and lymph nodes started on 11-8-2010, HDR Brachytherapy December 6 and 13, 2010.
PSA < .1 since February 2011. Located in Cumming Georgia north of Atlanta
Post Edited (JNF) : 4/9/2018 9:13:38 AM (GMT-6)