Want to get back to the topic of my post and refine questions:
1. Do you take iron supplements to help with ADT caused anemia ?
(esp if your diet does not have a lot of iron)
if so, what type of iron and how much a day
ie ferrous sulphate, ferrous fumarate, chelated, etc ?
and how many mg of elemental iron each day ?
2. Has taking the iron supplements helped you blood count numbers ie hemoglobin, hematocrit, RBC ?
3. Do you take vitamin B complex while on ADT ? Had read that some Vitamin B might not be good
re pca, but can't find that now ?
trailguy, thanks for your comments. on the exercise, it was good for me to read this as have
been lagging alot in doing that even though have felt it is important to help me in dealing with
adt and also overall energy and focus. I don't do as much as you do for sure but it would be
great if I can just get back to what I was doing.
I don't know of anything specific re: B12 taken with ADT. But there are these:/www.ncbi.nlm.nih.gov/pubmed/23508410
Vitamin B12, MMA and methionine concentrations were not associated with prostate cancer risk. Compared with the MTHFR 677CC genotype, the CT and TT variants, both of which were related to lower folate concentrations, were associated with reduced prostate cancer risk [OR 0.82 (0.72-0.94) and OR 0.78 (0.64-0.94), respectively].
This large-scale population-based study suggests that high serum folate concentration may be associated with modestly increased prostate cancer risk. We did not observe an association between vitamin B12 status and prostate cancer risk.
In the ProtecT study, increased B(12) and holo-haptocorrin concentrations showed positive associations with prostate cancer risk [highest versus lowest quartile of B(12) odds ratio (OR) = 1.17 (95% confidence interval, 0.95-1.43); P(trend) = 0.06; highest versus lowest quartile of holo-haptocorrin OR = 1.27 (1.04-1.56); P(trend) = 0.01]; folate, holo-transcobalamin, and tHcy were not associated with prostate cancer risk. In the meta-analysis, circulating B(12) levels were associated with an increased prostate cancer risk [pooled OR = 1.10 (1.01-1.19) per 100 pmol/L increase in B(12); P = 0.002]; the pooled OR for the association of folate with prostate cancer was positive [OR = 1.11 (0.96-1.28) per 10 nmol/L; P = 0.2) and conventionally statistically significant if ProtecT (the only case-control study) was excluded [OR = 1.18 (1.00-1.40) per 10 nmol/L; P = 0.02].
Vitamin B(12) and (in cohort studies) folate were associated with increased prostate cancer risk.
Given current controversies over mandatory fortification, further research is needed to determine whether these are causal associations.
Those associations seem pretty small to me, or inconsistent, but they are there.
Of course, OTOH, no one can get by without adequate B12, and in the case of any treatment causing anemia, it might be that the odds of a bad outcome from not enough of it would far outweigh any slight increase of odds for promoting PC, if that increase even exists. Finally, risk(high vs low) is not mentioned, nor is mortality, just PC in general.
There are more than one study out there that indicate that while nutrient/food/ XYZ(whatever) either has no benefit for lowering odds of getting low risk PC, and maybe even(by association at least, which is not the same as cause) slightly increases the odds of getting PC, when it comes to high risk PC and/or PC mortality, it is often quite the opposite. It is associated with- in several studies at least- less mortality and a lower risk score(i.e. lower Gleason scores, stage, etc).
Could be the same regarding the small association in these studies of B12(and/or folate) with PC. It might be that the main thing it is associated with is low risk PC, while it is not associated with high risk or mortality, and possibly even reduces the chance of those. Unless someone has other studies indicating otherwise, I'd say we don't really know. But like I said, with or without PC, we need a certain amount of B12.
Post Edited (BillyBob@388) : 4/13/2018 1:32:44 PM (GMT-6)