Saipan Paradise said...
Here's a 2018 paper you might find interesting: Management of Biochemical Recurrence after Primary Curative Treatment for Prostate Cancer: A Review
It states, "Within 10 years, 20-40% of post-RP and 30-50% of post-RT patients will experience BCR."
I found those statistics surprising. The post-RT number is from a 2006 study -- pretty old considering the advances in PCa treatment in the past decade and the lag time to gather evidence of BCR, so there's reason to doubt the numbers are so high.
Agree on the RT data being old, so probably not as bad as it seems. Still, the OP question being about
why so much RP BCR, when according to the older data t was actually worse with RT? So, assuming that RT has improved more than surgery since then, what is the current status? Is RT now equal, or a little better, or a lot better?
One reason right off that I can see why we would think - based on what we see here- that there are way more failures with surgery: until very recently, didn't the majority of folks choose surgery? Therefore, if results were even equal, we would see more "I have a BCR"threads for surgery guys, since more of us- in past years- have had surgery.
Also keep in mind the study a couple of years ago of 31000(!) HIGH RISK surgery guys. That is the worst group for surgery, right, since the horse likely has already left the barn? But as much as 25 years later(starting with mean age 62 and going through age 87!), CANCER SPECIFIC SURVIVAL was still 69%! And only 13% had ART. Considering that all were G8-10, and that surely means some had escaped the prostate bed, the results are to me, amazing! /www.ncbi.nlm.nih.gov/pubmed/24510158
Post Edited (BillyBob@388) : 10/10/2018 3:03:08 PM (GMT-6)