Resistance to these drugs is so rare that it shouldn't be a concern. Soon enough you will be wishing the side effects hadn't come on so soon. Eligard was developed as the generic version of Lupron, but does have a little different version of delivery.
Remember that the Leuprolide drugs like Lupron and Eligard will first boost your testosterone as the body tries to counteract the drug's action. That is why Casodex is used to offset the T flare. This takes a few weeks to settle in before the T production stops. Then a few weeks for the T to metabolize out of your body so the side effects of no T can begin. So the 6-8 weeks is normal to see the side effects. For me, my first shot was on October 6, 2010 and I didn't start having hot flashes until mid January, 2011. By the end of January my PSA was undetectable. My T was tested in March and is was single digit.
In my case I did have an unusual negative reaction to the drug (Eligard) that manifested a week after the shot, but several weeks before the normal side effects appear.
PSA 59 on 8-26-2010 age 60. Biopsy 9-8-2010 12/12 positive, 20-80% involved, PNI in 3 cores, G 3+3,3+4,and 4+3=G7, T2b.
Eligard and Jalyn started on 10-7-2010. IMRT to prostate and lymph nodes started on 11-8-2010, HDR Brachytherapy December 6 and 13, 2010.
PSA < .1 since February 2011. Located in Cumming Georgia north of Atlanta
Post Edited (JNF) : 12/3/2018 8:48:01 AM (GMT-7)