TV show, "The Good Doctor", Lupron story line

but on TV anything is possible and the worst always happens.

---

I'll be in the shop.
Age 58, 52 at DX
PSA:
4.2 10/11, 1.9 6/12, 1.2 12/12, 1.0 5/13, .6 11/13,
.7 5/14, .5 10/14, .5 4/15, .3 10/15, .3 4/16, .4 10/16, .4 5/17, .3 10/17 .3 4/18, .4 11/18
G 3+4
Stage T1C
2 out of 14 cores positive
Treatment IGRT - 2/2012

I guess cardiovascular issues in my mind didn't translate to strokes. Of course it is, but still, how often has anyone here discussed a stroke as a Lupron side effect? Ever? I don't recall anyone talking about it here.

Fatigue, hot flashes, "cognitive issues", physical changes, and so on. But a stroke? What's the risk of that?

This page from drugs.com doesn't even mention stroke. So implying, "Well, duh." isn't a good response.

Some places mention it sort of casually, like "increases risk of heart attack, sudden death, or stroke". Well, what does that mean? "Increases"? Like one out of a billion to two out of a billion? Or, one out of 10 to 5 out of 10?

Of course, old guys are commonly taking Lupron, and our population has a higher risk of stroke anyway. The character in this TV show was probably mid-30s to maybe 40-ish, so not old at all.

I think that in general those who die of a CV incident tend to die suddenly, and then they stop posting at HW/PC...so all we see (in numerous posts) are the up-front cautions. The increased risk for CV due to ADT is (statistically) significant (although it's low), and increases over time and there is additional evidence that the risk persists even after treatment ends, AND indirectly lupron causes other side effects (fatigue, weight gain, etc) which contribute to increased cardiovascular risks/issues.

Redwing57 said...
I guess cardiovascular issues in my mind didn't translate to strokes. Of course it is, but still, how often has anyone here discussed a stroke as a Lupron side effect? Ever? I don't recall anyone talking about it here.

Lol...how about YOUR post from last month, titled "Article: Complications of Androgen Deprivation Therapy in Men With Prostate Cancer." Or look at the thread titled "Lupron and heart failure" from this summer. Or the thread "Cardiovascular implications of ADT" shortly before that.

Don't get me wrong, it's not that everyone who has Lupron will die of CV. There is documented single digit increased risks (more, as I said, if preexisting CVD)...but as I wrote above, the risks and potential benefits have to be weighed and monitored. As I consistently say, "Treat the patient, not the number." Someone who has no CV disease would likely have little or no hesitation to take Lupron. But then again, with the average age of men diagnosed with PC close to 70, what percentage of 70 YOs have known CV...? Unknown CV...?

Most recent episode I watched is where Shaun and Lea got a goldfish which died. I really liked season 1, but the story lines are getting a bit wacky, which means a season 3 is less likely.

Post Edited (Blackjack) : 11/28/2018 3:43:13 PM (GMT-7)

F8 said...
the news says chemical castration

Yep...not surprised. Always in search of the eye-catching headline or ear-popping sound bite..."chemical castration" is going to get more attention to the news piece than any of the other ADT synonyms. You can envision the newscaster adding a little tilt of the head, a short pause before, and subtle additional emphasis...

Well, now I understand why I have not wanted to become a priest for the last five ears.

Blackjack, thanks for again reminding me of the usefulness of this forum's "ignore" feature.

RedWing said...
Still, I can't remember seeing Lupron ever discussed in a TV program before.

It was mentioned on several episodes of "House". I seem to recall three.

As for its use with sex criminals there are some states for which it is ordered for repeat-offending child molesters. (Louisiana for one, I think.) If you look at the Wikipedia page for "Chemical Castration" there is some information.

---

65 Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012: 1&2 neg, 3 pos 1/14 6(3+3) 3-4% (2^nd opn. 7(3+4)), 4 neg
DaVinci 6/14/12. "some" nerve sparing on left
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adj IMRT 66.6 Gy 10/17/12-12/13/12
8/2012-3/2015: Incont., Trimix, VED, PSA<0.015.
AUS & IPP installed 3/5/2015
Forum Moderator - Not a medical professional

Blackjack, before Lupron (on my 3rd 6 monther), I think I remember that, Lisa Edelstein, was "sexy" looking?
She could be "Lou" Edelstein, now as far as I am concerned?

And yes they actually said "Lupron" on the show, which I recorded for later viewing, last night!

Because of these risks, I try to jog a mile, at least 5 days a week, and pump heavy iron, at least 3 days. Try to keep those arteries cleaned out, just in case!

Just got my second PSA < 0.1, last week.

---

70,(1948) Troy MO-W of St. Louis
PSA's 3.2 (7/08), 51.2(7/11/17)
(7/24)DRE hd lft, 31g, (8/11)Biop GS 8s & 7s, 9of12
(8/29)NUC/CT Scans (-)
(9/11)Prolaris T2b, 3.8/10, 10yr Mort Rsk 24%, Met Rsk 30%.
(10/23)MRI 3T (-)
(11/15)RALP, PATH-T3b, GS9,70G, Pc 40%,PLN 3/7+,+Marg-apex,ureth,blad nk,SV
(11/21)Lupr/Cas
(1/2/18)Axumin scn (-)
(1/3)Markers
(2/20-4/16)IMRT-37 tx
(5/22)PSA<0.10
(5/30) Lupr/noCas