The hypothalamus is on top of and intimately connected with the pituitary gland. The hypothalamus controls what and how much the pituitary gland produces. It acts like a moderating link between your nervous system and all of your other organs. On a regular basis, it releases a small, precise amount of a particular chemical that turns on a bunch of organs, including the sex glands. Those then make sex hormones like testosterone. As this is done, it uses up that original chemical. When the hypothalamus senses the lowered levels, it releases some more. When the chemical levels are low, the functions they control go low as well, like lower sex hormones produced.
Luprolides are chemicals that engage and saturate receptors in the hypothalamus continuously and completely. The intent is to stop all production of sex hormones for long periods of time in order to slow the progression of hormone sensitive cancers. They work well at that. That is not all they do, however. A look at the side effects listed by the manufacturers and an understanding of the limited role that sex hormones play in those
side effects show how they work by 'jamming' the hypothalamus and thus the pituitary.
6 years ago, when I started Firmagon, then Lupron, then Eligard, I researched this and connected the dots. I then requested intermittent measuring of my pituitary hormones along with my testosterone and PSA levels. They all crashed while I was on the chems. They all came back up into normal ranges as the chems wore off.
Well, excepting for my testosterone due to the demise of 1 testicle.
"Lupron® is an “antineoplastic agent”, meaning that it is a cancer chemotherapy drug. Like all antineoplastics, Lupron® is harmful to both cancerous and non-cancerous cells — particularly to pregnant women and developing fetuses. ... The popular website, Drugs.com, states flatly: “Lupron causes birth defects."
Not saying not to take the stuff though, as it does help the fight. It helps to understand why things are happening to me so I can deal better with them. I will be back on the chems pretty soon here myself, as I like to be alive.
b 1950, 2012 PSA=11, 12/12 cores +. DVRP 12/27/12. 36 g gland 35% PCa,EC ext., 2 SV+,+ marg T3bNXMX, G7(4+3). 2 week post-RP PSA=0.2, Firmagon ADT. Cont @ 3 mo, EBRT prostate bed and interior pelvic lymph nodes ~ 80 Gy/40 ses. Last 6 mo. Eligard 10/14. 4/15 T=2.2, PSA<.02. 10/16 T=204, PSA=.08, 2/17 PSA=.13, 3/17 T=307 PSA=.19, 4/17 PSA=.21, 4/18 PSA=.65 6/18 PSA=1.15 8/18 PSA=1.15 11/18 PSA=1.58